Tau蛋白聚集:神经退行性疾病的治疗靶点。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Aryan Duggal, Drishti Mahindru, Kirti Baghel, Sanjana Mehrotra, Vijay Kumar Prajapati
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引用次数: 0

摘要

Tau蛋白是神经元结构的关键元素,在许多神经退行性疾病,特别是阿尔茨海默病和其他Tau病中具有致病性。在正常情况下,tau稳定微管并支持必要的细胞运输系统。然而,在疾病状态下,tau蛋白经历异常修饰——最明显的是过度磷酸化——导致其从微管中分离并聚集成神经原纤维缠结。这些聚集物破坏神经元功能,导致进行性认知和运动缺陷。本章全面概述了tau蛋白的结构特性、正常细胞的作用以及将其转化为神经毒性物质的一系列病理变化。我们研究了目前针对tau的治疗策略,包括抑制其磷酸化,防止其聚集,并增强其从细胞中的清除能力。激酶抑制剂、免疫疗法和基于基因的疗法等方法在其停止或减缓疾病进展的潜力的背景下进行了讨论。此外,诊断工具的最新进展,如tau特异性PET成像和血液生物标志物,被强调为疾病早期检测的变革。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tau protein aggregation: A therapeutic target for neurodegenerative diseases.

Tau protein, a critical element for neuronal structure, becomes pathogenic in numerous neurodegenerative diseases, particularly Alzheimer's disease and other tauopathies. Under normal conditions, tau stabilizes microtubules and supports essential cellular transport systems. However, in disease states, tau undergoes abnormal modifications-most notably hyperphosphorylation-causing it to detach from microtubules and aggregate into neurofibrillary tangles. These aggregates disrupt neuronal function, leading to progressive cognitive and motor deficits. This chapter provides a comprehensive overview of tau's structural properties, normal cellular roles, and the cascade of pathological changes that transform it into a neurotoxic agent. We examine current therapeutic strategies targeting tau, including efforts to inhibit its phosphorylation, prevent aggregation, and enhance its clearance from cells. Approaches such as kinase inhibitors, immunotherapies, and gene-based therapies are discussed in the context of their potential to halt or slow disease progression. Additionally, recent advancements in diagnostic tools-such as tau-specific PET imaging and blood biomarkers-are highlighted as transformative for early detection of the disease .

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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