Lucia Mangone , Francesco Marinelli , Isabella Bisceglia , Angelina Filice , Maria Barbara Braghiroli , Francesca Roncaglia , Andrea Palicelli , Fortunato Morabito , Antonino Neri , Roberto Sabbatini , Cinzia Iotti , Carmine Pinto
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This study aims to evaluate the influence of Gleason, stage and age on surgery and radiotherapy.</div></div><div><h3>Methods</h3><div>In a province of northern Italy were analyzed 1381 prostate cancers diagnosed between 2018 and 2022, focusing on trends in age, stage, Gleason and treatment.</div></div><div><h3>Results</h3><div>Over the study period, there was slight a decline in stage I (39%, 42%, 36%, 28%, 38%) and Gleason 6 (26%, 28%, 28%, 18%, 26%), along with an increase in stage IV (13%, 13%, 15%, 20%, 16%) and Gleason 8-10 (20%, 21%, 21%, 26%, and 28%). Surgery and radiation therapy remained constant at 34% and 40%, respectively. The likelihood of receiving surgery decreased in patients aged 70-79 [OR 0.35; 0.21-0.58] and 80+ [OR 0.03; 0.02-0.07] and increased in Gleason 7 [OR 1.83; 1.27-2.65] and stage II [OR 3.89; 2.74-5.51] and III [OR 9.77; 6.34-15.05]. The possibility of receiving radiotherapy increases in patients aged 70-79 [OR 2.85; 1.75-4.65] and 80+ [OR 2.11; 1.24-3.60] and in patients with Gleason 7 [OR 1.95; 1.42-2.68] and 8-10 [OR 2.95; 1.96-4.46].</div></div><div><h3>Conclusions</h3><div>During the period there was a slight shift toward more aggressive prostate cancers, but treatments remained stable.</div></div>","PeriodicalId":10380,"journal":{"name":"Clinical genitourinary cancer","volume":"23 4","pages":"Article 102383"},"PeriodicalIF":2.3000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Gleason, Stage and Age on Surgery and Radiotherapy in Prostate Cancer Patients in Northern Italy\",\"authors\":\"Lucia Mangone , Francesco Marinelli , Isabella Bisceglia , Angelina Filice , Maria Barbara Braghiroli , Francesca Roncaglia , Andrea Palicelli , Fortunato Morabito , Antonino Neri , Roberto Sabbatini , Cinzia Iotti , Carmine Pinto\",\"doi\":\"10.1016/j.clgc.2025.102383\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>The incidence of prostate cancer is increasing due to the aging and early diagnosis. This study aims to evaluate the influence of Gleason, stage and age on surgery and radiotherapy.</div></div><div><h3>Methods</h3><div>In a province of northern Italy were analyzed 1381 prostate cancers diagnosed between 2018 and 2022, focusing on trends in age, stage, Gleason and treatment.</div></div><div><h3>Results</h3><div>Over the study period, there was slight a decline in stage I (39%, 42%, 36%, 28%, 38%) and Gleason 6 (26%, 28%, 28%, 18%, 26%), along with an increase in stage IV (13%, 13%, 15%, 20%, 16%) and Gleason 8-10 (20%, 21%, 21%, 26%, and 28%). Surgery and radiation therapy remained constant at 34% and 40%, respectively. The likelihood of receiving surgery decreased in patients aged 70-79 [OR 0.35; 0.21-0.58] and 80+ [OR 0.03; 0.02-0.07] and increased in Gleason 7 [OR 1.83; 1.27-2.65] and stage II [OR 3.89; 2.74-5.51] and III [OR 9.77; 6.34-15.05]. 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Impact of Gleason, Stage and Age on Surgery and Radiotherapy in Prostate Cancer Patients in Northern Italy
Background
The incidence of prostate cancer is increasing due to the aging and early diagnosis. This study aims to evaluate the influence of Gleason, stage and age on surgery and radiotherapy.
Methods
In a province of northern Italy were analyzed 1381 prostate cancers diagnosed between 2018 and 2022, focusing on trends in age, stage, Gleason and treatment.
Results
Over the study period, there was slight a decline in stage I (39%, 42%, 36%, 28%, 38%) and Gleason 6 (26%, 28%, 28%, 18%, 26%), along with an increase in stage IV (13%, 13%, 15%, 20%, 16%) and Gleason 8-10 (20%, 21%, 21%, 26%, and 28%). Surgery and radiation therapy remained constant at 34% and 40%, respectively. The likelihood of receiving surgery decreased in patients aged 70-79 [OR 0.35; 0.21-0.58] and 80+ [OR 0.03; 0.02-0.07] and increased in Gleason 7 [OR 1.83; 1.27-2.65] and stage II [OR 3.89; 2.74-5.51] and III [OR 9.77; 6.34-15.05]. The possibility of receiving radiotherapy increases in patients aged 70-79 [OR 2.85; 1.75-4.65] and 80+ [OR 2.11; 1.24-3.60] and in patients with Gleason 7 [OR 1.95; 1.42-2.68] and 8-10 [OR 2.95; 1.96-4.46].
Conclusions
During the period there was a slight shift toward more aggressive prostate cancers, but treatments remained stable.
期刊介绍:
Clinical Genitourinary Cancer is a peer-reviewed journal that publishes original articles describing various aspects of clinical and translational research in genitourinary cancers. Clinical Genitourinary Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of genitourinary cancers. The main emphasis is on recent scientific developments in all areas related to genitourinary malignancies. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.