Gleason,分期和年龄对意大利北部前列腺癌患者手术和放疗的影响

IF 2.3 3区 医学 Q3 ONCOLOGY
Lucia Mangone , Francesco Marinelli , Isabella Bisceglia , Angelina Filice , Maria Barbara Braghiroli , Francesca Roncaglia , Andrea Palicelli , Fortunato Morabito , Antonino Neri , Roberto Sabbatini , Cinzia Iotti , Carmine Pinto
{"title":"Gleason,分期和年龄对意大利北部前列腺癌患者手术和放疗的影响","authors":"Lucia Mangone ,&nbsp;Francesco Marinelli ,&nbsp;Isabella Bisceglia ,&nbsp;Angelina Filice ,&nbsp;Maria Barbara Braghiroli ,&nbsp;Francesca Roncaglia ,&nbsp;Andrea Palicelli ,&nbsp;Fortunato Morabito ,&nbsp;Antonino Neri ,&nbsp;Roberto Sabbatini ,&nbsp;Cinzia Iotti ,&nbsp;Carmine Pinto","doi":"10.1016/j.clgc.2025.102383","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>The incidence of prostate cancer is increasing due to the aging and early diagnosis. This study aims to evaluate the influence of Gleason, stage and age on surgery and radiotherapy.</div></div><div><h3>Methods</h3><div>In a province of northern Italy were analyzed 1381 prostate cancers diagnosed between 2018 and 2022, focusing on trends in age, stage, Gleason and treatment.</div></div><div><h3>Results</h3><div>Over the study period, there was slight a decline in stage I (39%, 42%, 36%, 28%, 38%) and Gleason 6 (26%, 28%, 28%, 18%, 26%), along with an increase in stage IV (13%, 13%, 15%, 20%, 16%) and Gleason 8-10 (20%, 21%, 21%, 26%, and 28%). Surgery and radiation therapy remained constant at 34% and 40%, respectively. The likelihood of receiving surgery decreased in patients aged 70-79 [OR 0.35; 0.21-0.58] and 80+ [OR 0.03; 0.02-0.07] and increased in Gleason 7 [OR 1.83; 1.27-2.65] and stage II [OR 3.89; 2.74-5.51] and III [OR 9.77; 6.34-15.05]. The possibility of receiving radiotherapy increases in patients aged 70-79 [OR 2.85; 1.75-4.65] and 80+ [OR 2.11; 1.24-3.60] and in patients with Gleason 7 [OR 1.95; 1.42-2.68] and 8-10 [OR 2.95; 1.96-4.46].</div></div><div><h3>Conclusions</h3><div>During the period there was a slight shift toward more aggressive prostate cancers, but treatments remained stable.</div></div>","PeriodicalId":10380,"journal":{"name":"Clinical genitourinary cancer","volume":"23 4","pages":"Article 102383"},"PeriodicalIF":2.3000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Gleason, Stage and Age on Surgery and Radiotherapy in Prostate Cancer Patients in Northern Italy\",\"authors\":\"Lucia Mangone ,&nbsp;Francesco Marinelli ,&nbsp;Isabella Bisceglia ,&nbsp;Angelina Filice ,&nbsp;Maria Barbara Braghiroli ,&nbsp;Francesca Roncaglia ,&nbsp;Andrea Palicelli ,&nbsp;Fortunato Morabito ,&nbsp;Antonino Neri ,&nbsp;Roberto Sabbatini ,&nbsp;Cinzia Iotti ,&nbsp;Carmine Pinto\",\"doi\":\"10.1016/j.clgc.2025.102383\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>The incidence of prostate cancer is increasing due to the aging and early diagnosis. This study aims to evaluate the influence of Gleason, stage and age on surgery and radiotherapy.</div></div><div><h3>Methods</h3><div>In a province of northern Italy were analyzed 1381 prostate cancers diagnosed between 2018 and 2022, focusing on trends in age, stage, Gleason and treatment.</div></div><div><h3>Results</h3><div>Over the study period, there was slight a decline in stage I (39%, 42%, 36%, 28%, 38%) and Gleason 6 (26%, 28%, 28%, 18%, 26%), along with an increase in stage IV (13%, 13%, 15%, 20%, 16%) and Gleason 8-10 (20%, 21%, 21%, 26%, and 28%). Surgery and radiation therapy remained constant at 34% and 40%, respectively. The likelihood of receiving surgery decreased in patients aged 70-79 [OR 0.35; 0.21-0.58] and 80+ [OR 0.03; 0.02-0.07] and increased in Gleason 7 [OR 1.83; 1.27-2.65] and stage II [OR 3.89; 2.74-5.51] and III [OR 9.77; 6.34-15.05]. The possibility of receiving radiotherapy increases in patients aged 70-79 [OR 2.85; 1.75-4.65] and 80+ [OR 2.11; 1.24-3.60] and in patients with Gleason 7 [OR 1.95; 1.42-2.68] and 8-10 [OR 2.95; 1.96-4.46].</div></div><div><h3>Conclusions</h3><div>During the period there was a slight shift toward more aggressive prostate cancers, but treatments remained stable.</div></div>\",\"PeriodicalId\":10380,\"journal\":{\"name\":\"Clinical genitourinary cancer\",\"volume\":\"23 4\",\"pages\":\"Article 102383\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-06-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical genitourinary cancer\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1558767325000837\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical genitourinary cancer","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1558767325000837","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

研究背景随着年龄的增长和早期诊断,前列腺癌的发病率不断上升。本研究旨在探讨Gleason、分期及年龄对手术及放疗的影响。方法对意大利北部某省2018年至2022年间诊断的1381例前列腺癌进行分析,重点关注年龄、分期、格里森和治疗的趋势。结果在研究期间,I期(39%、42%、36%、28%、38%)和Gleason 6期(26%、28%、28%、18%、26%)略有下降,IV期(13%、13%、15%、20%、16%)和Gleason 8-10期(20%、21%、21%、26%、28%)略有增加。手术和放射治疗保持不变,分别为34%和40%。70-79岁患者接受手术的可能性降低[OR 0.35;0.21-0.58]和80+ [OR 0.03;0.02-0.07], Gleason 7增高[OR 1.83;1.27-2.65]和II期[OR 3.89;2.74-5.51]和III [OR 9.77;6.34 - -15.05)。70-79岁患者接受放疗的可能性增加[OR 2.85;1.75-4.65]和80+ [OR 2.11;[1.24-3.60]和Gleason 7患者[OR 1.95;1.42-2.68]和8-10 [OR 2.95;1.96 - -4.46)。结论:在此期间,前列腺癌有轻微的转移,但治疗保持稳定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Gleason, Stage and Age on Surgery and Radiotherapy in Prostate Cancer Patients in Northern Italy

Background

The incidence of prostate cancer is increasing due to the aging and early diagnosis. This study aims to evaluate the influence of Gleason, stage and age on surgery and radiotherapy.

Methods

In a province of northern Italy were analyzed 1381 prostate cancers diagnosed between 2018 and 2022, focusing on trends in age, stage, Gleason and treatment.

Results

Over the study period, there was slight a decline in stage I (39%, 42%, 36%, 28%, 38%) and Gleason 6 (26%, 28%, 28%, 18%, 26%), along with an increase in stage IV (13%, 13%, 15%, 20%, 16%) and Gleason 8-10 (20%, 21%, 21%, 26%, and 28%). Surgery and radiation therapy remained constant at 34% and 40%, respectively. The likelihood of receiving surgery decreased in patients aged 70-79 [OR 0.35; 0.21-0.58] and 80+ [OR 0.03; 0.02-0.07] and increased in Gleason 7 [OR 1.83; 1.27-2.65] and stage II [OR 3.89; 2.74-5.51] and III [OR 9.77; 6.34-15.05]. The possibility of receiving radiotherapy increases in patients aged 70-79 [OR 2.85; 1.75-4.65] and 80+ [OR 2.11; 1.24-3.60] and in patients with Gleason 7 [OR 1.95; 1.42-2.68] and 8-10 [OR 2.95; 1.96-4.46].

Conclusions

During the period there was a slight shift toward more aggressive prostate cancers, but treatments remained stable.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Clinical genitourinary cancer
Clinical genitourinary cancer 医学-泌尿学与肾脏学
CiteScore
5.20
自引率
6.20%
发文量
201
审稿时长
54 days
期刊介绍: Clinical Genitourinary Cancer is a peer-reviewed journal that publishes original articles describing various aspects of clinical and translational research in genitourinary cancers. Clinical Genitourinary Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of genitourinary cancers. The main emphasis is on recent scientific developments in all areas related to genitourinary malignancies. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信