代谢功能障碍相关脂肪肝疾病、血清代谢物与认知功能轨迹的纵向关联。

Anxin Wang, Xue Tian, Qiqi Deng, Manqi Zheng, Xue Xia, Yijun Zhang, Yan Tan, Qian Hua
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引用次数: 0

摘要

本研究考察了代谢功能障碍相关脂肪性肝病(MAFLD)与不同认知功能轨迹的纵向关联,并在845名参与者中确定这种关联是否以及在多大程度上由MAFLD相关代谢物介导。7年内认知功能轨迹分为正常(n = 714, 84.50%)和大幅下降(n = 131, 15.50%)两种模式。患有MAFLD的参与者(N = 277, 32.78%)发生认知功能大幅下降的风险高出81%(优势比,1.81;95%可信区间,1.16-2.94)。鉴定出3种与MAFLD相关的代谢物分别为lysoPC(20:3(5z,8z,11z))、lysoPE(18:1(9z)/0:0)和缬氨酸,其中lysoPE(18:1(9z)/0:0)和缬氨酸在MAFLD与认知功能大幅下降的关联中起部分介导作用(介导比例分别为9.93%和11.04%)。结果表明,MAFLD与认知功能大幅下降的高风险相关,这部分是由脂质和氨基酸代谢介导的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Longitudinal association of metabolic dysfunction-associated fatty liver disease, serum metabolites, with cognitive function trajectories.

This study examined the longitudinal association of metabolic dysfunction-associated fatty liver disease (MAFLD) with distinct cognitive function trajectories, and determine whether and to what extent this association was mediated by MAFLD-related metabolites among 845 participants. Two cognitive function trajectories were identified as normal (n = 714, 84.50%) or large decrease (n = 131, 15.50%) pattern over 7 years. Participants with MAFLD (N = 277, 32.78%) had an 81% higher risk of developing a large decrease in cognitive function (odds ratio, 1.81; 95% confidence interval, 1.16-2.94) than non-MAFLD. Three MAFLD-related metabolites were identified as lysoPC(20:3(5z,8z,11z)), lysoPE(18:1(9z)/0:0), and valine, of which lysoPE(18:1(9z)/0:0) and valine played a partially mediated role in the association of MAFLD with a large decrease in cognitive function (mediation proportion = 9.93% and 11.04%, respectively). The results indicated that MAFLD was associated with a higher risk of developing a large decrease in cognitive function, which was partially mediated by lipid and amino acid metabolism.

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