单次x射线声层析成像放射治疗基准标记跟踪的可行性。

IF 2.8 4区 医学 Q3 ONCOLOGY
Technology in Cancer Research & Treatment Pub Date : 2025-01-01 Epub Date: 2025-07-02 DOI:10.1177/15330338251342867
Norman Alexis Cantú-Delgado, Héctor Mauricio Garnica-Garza
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引用次数: 0

摘要

在放射治疗中,基准标记物提高了放射传递的准确性,它们的使用在治疗各种癌症,特别是前列腺癌和肺癌方面变得越来越重要。这项工作旨在通过蒙特卡罗模拟和数值超声传输来确定通过单次x射线声学计算机断层扫描进行基准标记定位的可行性。方法利用前列腺和肺两个治疗部位的CT扫描数据来模拟基础标记物定位过程。采用蒙特卡罗模拟计算了在短脉冲照射剂量的情况下,在120 kVp x射线成像源照射下,每位患者的吸收剂量分布。通过数值超声传输包k-Wave模拟每个患者的超声传输。在图像重建过程中,由于在治疗时不知道患者的确切内部结构,因此使用具有患者外部轮廓和尺寸的均匀介质。结果表明,在重建过程中使用均匀模型来近似患者的实际材料组成,这是必要的,因为在治疗时不知道内部结构的几何形状,严重降低了x射线声层析成像的质量,但仍然有可能确定基准标记位置,精度为1 mm或更好。当肺部处于充气状态时,观察到最大的误差。结论:单次x线声层析成像是一种有效的放射治疗基准标记物的跟踪和定位工具,尽管所得图像的视觉质量较差,但其精度优于1 mm。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Feasibility of Radiotherapy Fiducial Marker Tracking via Single-Shot X-ray Acoustic Tomography.

Feasibility of Radiotherapy Fiducial Marker Tracking via Single-Shot X-ray Acoustic Tomography.

Feasibility of Radiotherapy Fiducial Marker Tracking via Single-Shot X-ray Acoustic Tomography.

Feasibility of Radiotherapy Fiducial Marker Tracking via Single-Shot X-ray Acoustic Tomography.

Introductionin radiotherapy, fiducial markers improve the accuracy of radiation delivery, and their use has become increasingly important in the treatment of various cancers, particularly those in the prostate and lung. This work aims to determine, via Monte Carlo simulations and numerical ultrasound transport, the feasibility of fiducial marker localization via single-shot x-ray acoustic computed tomography.Methodspatient data from CT scans for two treatment sites, prostate and lung, were used to model the fiducial marker localization process. Monte Carlo simulation was used to calculate the absorbed dose distribution in each patient resulting from the irradiation with a 120 kVp x-ray imaging source, assuming that the dose is imparted in a short pulse. Ultrasound transport through each patient was modeled with the numerical ultrasound transport package k-Wave. For the image reconstruction process, as the exact internal patient structure will not be known at the time of treatment, a homogenous medium with the patient external contour and dimensions was used.ResultsIt is shown that the use of a homogeneous model to approximate the actual patient material composition during the reconstruction process, necessary as the geometry of the internal structures is not known at the time of the treatment, severely degrades the quality of the x-ray acoustic tomography images, but that it is still possible to determine the fiducial marker position with an accuracy of or better than 1 mm. The largest errors are observed for the lung patient when the lung is in an inflated state.Conclusionsit has been shown that single-shot x-ray acoustic tomography can be an effective tool for the tracking and localization of radiotherapy fiducial markers, exhibiting an accuracy of better than 1 mm, despite the poor visual quality of the resultant images.

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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
202
审稿时长
2 months
期刊介绍: Technology in Cancer Research & Treatment (TCRT) is a JCR-ranked, broad-spectrum, open access, peer-reviewed publication whose aim is to provide researchers and clinicians with a platform to share and discuss developments in the prevention, diagnosis, treatment, and monitoring of cancer.
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