晚期青光眼10-2视野丧失与结构和血管造影参数的相关性研究。

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2025-08-01 Epub Date: 2025-07-03 DOI:10.1007/s40123-025-01192-1

Kübra Atay Dinçer, Metehan Karaatlı, Onur Özalp, Tülay Şimşek, Monisha Esther Nongpiur, Eray Atalay

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引用次数: 0

摘要

摘要：我们研究了晚期青光眼患者光学相干断层扫描（OCT）血管造影（OCTA）衍生血管参数、中央视野（10-2 VF）、神经节细胞复合体（GCC）和视网膜神经纤维层（RNFL）厚度之间的关系。方法：本回顾性横断面研究纳入23例晚期青光眼患者的28只眼（24-2测试时VF平均偏差[MD] < - 12 dB）。所有参与者均进行了全面的眼科检查、OCT、OCTA和10-2 VF测试。Pearson相关性用于评估结构、功能和血管参数之间的关系。结果：GCC厚度与10-2 VF MD呈正相关（r = 0.529, p = 0.005），中央凹旁浅毛细血管丛血管密度（SCP-VD）与10-2 VF MD呈正相关（r = 0.549, p = 0.002）。黄斑SCP血管面积密度与RNFL厚度呈正相关（r = 0.429, p = 0.036）。视神经头层血管平均长度与10-2 VF MD呈负相关（r = - 0.528, p = 0.003）。象限分析显示，SCP-VD与上半场GCC （r = 0.409, p = 0.038）和RNFL厚度（r = 0.410, p = 0.047）呈正相关，与下半场深毛丛血管密度和RNFL厚度（r = 0.533, p = 0.007）呈正相关。结论：中央凹旁SCP-VD和GCC厚度，由于它们与10-2 VF MD显著相关，可以作为监测中央性视觉功能和晚期青光眼疾病进展的替代标记，特别是在可靠的VF检测不可行的情况下。

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Correlating 10-2 Visual Field Loss with Structural and Angiographic Parameters in Advanced Glaucoma.

Introduction: We investigated the relationship between optical coherence tomography (OCT) angiography (OCTA)-derived vascular parameters, central visual field (10-2 VF), ganglion cell complex (GCC), and retinal nerve fiber layer (RNFL) thickness in patients with advanced glaucoma.

Methods: This retrospective, cross-sectional study included 28 eyes of 23 patients with advanced glaucoma (VF mean deviation [MD] worse than - 12 dB on 24-2 testing). All participants underwent comprehensive ophthalmic examinations, OCT, OCTA, and 10-2 VF tests. Pearson's correlation was used to assess relationships between structural, functional, and vascular parameters.

Results: Statistically significant positive correlations were found between GCC thickness and 10-2 VF MD (r = 0.529, p = 0.005), and between parafoveal superficial capillary plexus vessel density (SCP-VD) and 10-2 VF MD (r = 0.549, p = 0.002). Macular SCP vessel area density showed a positive correlation with RNFL thickness (r = 0.429, p = 0.036). Mean vessel length in the optic nerve head layer exhibited a negative correlation with 10-2 VF MD (r = - 0.528, p = 0.003). Quadrant-wise analysis revealed positive associations between SCP-VD and both GCC (r = 0.409, p = 0.038) and RNFL thickness (r = 0.410, p = 0.047) in the superior hemifield, and between deep capillary plexus vessel density and RNFL thickness (r = 0.533, p = 0.007) in the inferior hemifield.

Conclusion: Parafoveal SCP-VD and GCC thickness, due to their significant correlations with 10-2 VF MD, may serve as surrogate markers for monitoring central visual function and disease progression in advanced glaucoma, particularly when reliable VF testing is not feasible.

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

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