肾脏病随机临床试验的创新：从研究设计到患者行动主义。

Q4 Medicine

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia Pub Date : 2025-06-30 DOI:10.69097/42-03-2025-02

Giuseppe Pezzi, Roberta Arena, Giuliana Papalia, Raffaella Sbano, Fiorella Iorio, Chiara Summaria, Angela Greco, Rosita Greco, Rocco Malivindi, Pierangelo Veltri, Gaetano La Manna, Lilio Hu, Gianluigi Zaza, Michele Provenzano

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引用次数: 0

摘要

目前的临床实践是由随机临床试验（RCT）的新有力证据指导的。这些研究通常遵循严格的前瞻性设计，在随访期间预先定义访问和计划检查。在肾脏病学的背景下，随机对照试验主要用于测试新疗法在降低肾衰竭风险、肾小球滤过率下降和死亡率或心血管事件方面的疗效。然而，信息学的进步反映在当前和未来随机对照试验的技术和创新的改进和扩展上。在此，我们就慢性肾脏疾病患者的随机对照试验的一些创新和未来发展方向进行了介绍。

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Innovations in randomized clinical trials in Nephrology: from study design to patient's activism.

Current clinical practice is guided by novel robust evidence from randomized clinical trials (RCT). These studies usually follow a rigorous prospective design with pre-defined visits and planned exams during follow-up. In the context of Nephrology, RCTs have been mainly designed to test the efficacy of new therapies in reducing the risk for kidney failure, estimated Glomerular Filtration Rate decline and mortality or cardiovascular events. However, the progress of informatics is reflected in an improvement and expansion of technologies and innovations in present and future RCTs. We here present some innovations and future directions of RCTs in Chronic Kidney Disease patients.

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来源期刊

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia Medicine-Medicine (all)

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： Il Giornale Italiano di Nefrologia (GIN) è la rivista di educazione continua della Società Italiana di Nefrologia SIN ed è pubblicato bimestralmente. E" il più autorevole organo di informazione nefrologia disponibile a livello nazionale. Il giornale Italiano di Nefrologia offre la più aggiornata informazione medico-scientifica rivolta al nefrologo sotto forma di rassegne, casi clinici e articoli finalizzati all’Educazione Continua in Medicina, oltre ai notiziari ed agli atti dei congressi di questa prestigiosa Società Scientifica