Deciphering the Complexity: Nephrotic Syndrome in Autosomal Dominant Polycystic Kidney Disease - A Case Report and Literature Review.

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder characterized by the development of multiple renal cysts and the growth of total kidney volume, often leading to progressive kidney failure. While glomerulonephritis is potentially recognized as a complication, the presence of glomerulonephritis among ADPKD patients is considered uncommon, and the incidence of nephrotic syndrome within this population is exceptionally rare. We present a case of a young woman with ADPKD who developed nephrotic syndrome, likely due to minimal change disease. The diagnostic challenges, management strategies, and existing literature on this rare association are here comprehensively reviewed.