[细胞外囊泡在过敏原特异性免疫治疗中的作用]。

Masaya Matsuda, Takeshi Nabe
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引用次数: 0

摘要

过敏性疾病的发病率不断上升,对雪松花粉和屋尘螨等过敏原的致敏已成为一个社会问题。过敏性炎症主要由2型炎症驱动,2型炎症由Th2细胞和2组先天淋巴样细胞(ILC2s)产生的白细胞介素(IL)-4、IL-5和IL-13介导。最近的研究表明,细胞外囊泡(EV)在变应性疾病的发病机制中也起着重要作用。EVs是含有蛋白质、mRNA和microRNA (miRNA)的脂质双层封闭颗粒,作为细胞因子、抗原和miRNA的载体,激活Th2细胞和ILC2s,参与各种炎症性疾病的进展。相反,我们证明了ev有助于过敏性疾病的消退:来自过敏原免疫治疗小鼠血清的ev抑制了ILC2的激活。鉴于其在促进和抑制免疫反应中的双重作用,ev正在成为新的治疗策略的有希望的靶点和工具。了解ev介导的免疫调节机制将是开发更安全、更有效的过敏性疾病治疗方法的关键一步。本文综述了ev在变应性炎症中的作用,并重点介绍了我们最近在过敏原免疫治疗如何影响ev的性质和功能,从而有助于调节免疫反应和减轻过敏症状方面的发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Roles of extracellular vesicles in allergen-specific immunotherapy].

The prevalence of allergic diseases has been increasing, and sensitization to allergens such as cedar pollen and house dust mites has become a social issue. Allergic inflammation is primarily driven by type 2 inflammation, which is mediated by interleukin (IL)-4, IL-5, and IL-13 produced by Th2 cells and group 2 innate lymphoid cells (ILC2s). Recent studies have suggested that extracellular vesicle (EV) also plays critical roles in the pathogenesis of allergic diseases. EVs are lipid bilayer-enclosed particles containing proteins, mRNA, and microRNA (miRNA), which function as carriers of cytokines, antigens, and miRNAs, thereby activating Th2 cells and ILC2s and contributing to the progression of various inflammatory diseases. In contrast, we demonstrated that EVs contributed to the regression of allergic disease: EVs derived from the serum of allergen immunotherapy-treated mice exhibited suppression of ILC2 activation. Given their dual roles in both promoting and suppressing immune responses, EVs are emerging as promising targets and tools for novel treatment strategies. Understanding the immunomodulatory mechanisms mediated by EVs will be a crucial step toward developing safer and more effective therapies for allergic diseases. This review provides an overview of the role of EVs in allergic inflammation and highlights our recent findings on how allergen immunotherapy influences the properties and functions of EVs, thereby contributing to the regulation of immune responses and alleviation of allergic symptoms.

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来源期刊
Folia Pharmacologica Japonica
Folia Pharmacologica Japonica Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
0.40
自引率
0.00%
发文量
132
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