日本男性和女性牙周病和糖尿病发生风险:一项为期12年的队列研究

IF 1.2 Q4 ENDOCRINOLOGY & METABOLISM
Diabetology International Pub Date : 2025-03-29 eCollection Date: 2025-07-01 DOI:10.1007/s13340-025-00815-z
Kazuka Yoneda, Masaru Sakurai, Yoshiyuki Soyama, Motoko Nakashima, Yuko Morikawa, Teruhiko Kido, Yuchi Naruse, Masao Ishizaki, Hideaki Nakagawa
{"title":"日本男性和女性牙周病和糖尿病发生风险:一项为期12年的队列研究","authors":"Kazuka Yoneda, Masaru Sakurai, Yoshiyuki Soyama, Motoko Nakashima, Yuko Morikawa, Teruhiko Kido, Yuchi Naruse, Masao Ishizaki, Hideaki Nakagawa","doi":"10.1007/s13340-025-00815-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims/introduction: </strong>This study assessed the association between periodontal disease and the development of diabetes mellitus, as well as the effects of sex differences and obesity on this association.</p><p><strong>Materials and methods: </strong>The study included 4051 employees (2497 men and 1554 women) aged 35-55 years at a metal product manufacturing company in Japan. Periodontal disease was assessed using the Community Periodontal Index. Diabetes mellitus was determined based on annual health checkups.</p><p><strong>Results: </strong>The prevalence of periodontal disease was 36.9% (41.9% in men and 29.5% in women). During the 12-year follow-up, 229 participants developed diabetes. The cumulative incidence rates (per 1000 person-years) were 10.1 for all participants, 7.8 for those without periodontal disease, and 14.5 for those with periodontal disease. The multivariate-adjusted hazard ratio (HR) for diabetes incidence in the periodontal disease group was 1.36 (95% confidence interval: 1.04-1.78); this was significantly higher than in the non-periodontal disease group. In men, the multivariate-adjusted HR for diabetes incidence was significantly higher in the periodontal disease group, at 1.37 (1.02-1.83), than in the non-periodontal disease group. No significant association was detected in women. When stratified according to sex and obesity status, the non-obese male group showed a significantly higher HR for diabetes incidence in the periodontal disease group (1.75 [1.15-2.66]) compared with the non-periodontal disease group.</p><p><strong>Conclusions: </strong>This 12-year prospective cohort study demonstrated that periodontal disease significantly increased the risk of diabetes; the association was more pronounced in men, particularly non-obese men.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13340-025-00815-z.</p>","PeriodicalId":11340,"journal":{"name":"Diabetology International","volume":"16 3","pages":"528-537"},"PeriodicalIF":1.2000,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209127/pdf/","citationCount":"0","resultStr":"{\"title\":\"Periodontal disease and the incident risk of diabetes mellitus in Japanese men and women: a 12-year cohort study.\",\"authors\":\"Kazuka Yoneda, Masaru Sakurai, Yoshiyuki Soyama, Motoko Nakashima, Yuko Morikawa, Teruhiko Kido, Yuchi Naruse, Masao Ishizaki, Hideaki Nakagawa\",\"doi\":\"10.1007/s13340-025-00815-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims/introduction: </strong>This study assessed the association between periodontal disease and the development of diabetes mellitus, as well as the effects of sex differences and obesity on this association.</p><p><strong>Materials and methods: </strong>The study included 4051 employees (2497 men and 1554 women) aged 35-55 years at a metal product manufacturing company in Japan. Periodontal disease was assessed using the Community Periodontal Index. Diabetes mellitus was determined based on annual health checkups.</p><p><strong>Results: </strong>The prevalence of periodontal disease was 36.9% (41.9% in men and 29.5% in women). During the 12-year follow-up, 229 participants developed diabetes. The cumulative incidence rates (per 1000 person-years) were 10.1 for all participants, 7.8 for those without periodontal disease, and 14.5 for those with periodontal disease. The multivariate-adjusted hazard ratio (HR) for diabetes incidence in the periodontal disease group was 1.36 (95% confidence interval: 1.04-1.78); this was significantly higher than in the non-periodontal disease group. In men, the multivariate-adjusted HR for diabetes incidence was significantly higher in the periodontal disease group, at 1.37 (1.02-1.83), than in the non-periodontal disease group. No significant association was detected in women. When stratified according to sex and obesity status, the non-obese male group showed a significantly higher HR for diabetes incidence in the periodontal disease group (1.75 [1.15-2.66]) compared with the non-periodontal disease group.</p><p><strong>Conclusions: </strong>This 12-year prospective cohort study demonstrated that periodontal disease significantly increased the risk of diabetes; the association was more pronounced in men, particularly non-obese men.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13340-025-00815-z.</p>\",\"PeriodicalId\":11340,\"journal\":{\"name\":\"Diabetology International\",\"volume\":\"16 3\",\"pages\":\"528-537\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-03-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209127/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diabetology International\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s13340-025-00815-z\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetology International","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13340-025-00815-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

摘要

目的/介绍:本研究评估了牙周病与糖尿病发展之间的关系,以及性别差异和肥胖对这种关系的影响。材料与方法:本研究包括日本一家金属制品制造公司的4051名员工(男性2497名,女性1554名),年龄在35-55岁之间。使用社区牙周指数评估牙周病。糖尿病是根据年度健康检查确定的。结果:牙周病患病率为36.9%,其中男性41.9%,女性29.5%。在12年的随访中,229名参与者患上了糖尿病。所有参与者的累积发病率(每1000人年)为10.1,无牙周病者为7.8,有牙周病者为14.5。牙周病组糖尿病发病率的多变量校正危险比(HR)为1.36(95%可信区间:1.04-1.78);这明显高于非牙周病组。在男性中,牙周病组糖尿病发病率的多变量调整HR显著高于非牙周病组,为1.37(1.02-1.83)。在女性中未发现显著相关性。按性别和肥胖状况分层,非肥胖男性牙周病组糖尿病发病率HR(1.75[1.15-2.66])明显高于非牙周病组。结论:这项为期12年的前瞻性队列研究表明,牙周病显著增加糖尿病的风险;这种关联在男性中更为明显,尤其是不肥胖的男性。补充信息:在线版本包含补充资料,下载地址为10.1007/s13340-025-00815-z。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Periodontal disease and the incident risk of diabetes mellitus in Japanese men and women: a 12-year cohort study.

Aims/introduction: This study assessed the association between periodontal disease and the development of diabetes mellitus, as well as the effects of sex differences and obesity on this association.

Materials and methods: The study included 4051 employees (2497 men and 1554 women) aged 35-55 years at a metal product manufacturing company in Japan. Periodontal disease was assessed using the Community Periodontal Index. Diabetes mellitus was determined based on annual health checkups.

Results: The prevalence of periodontal disease was 36.9% (41.9% in men and 29.5% in women). During the 12-year follow-up, 229 participants developed diabetes. The cumulative incidence rates (per 1000 person-years) were 10.1 for all participants, 7.8 for those without periodontal disease, and 14.5 for those with periodontal disease. The multivariate-adjusted hazard ratio (HR) for diabetes incidence in the periodontal disease group was 1.36 (95% confidence interval: 1.04-1.78); this was significantly higher than in the non-periodontal disease group. In men, the multivariate-adjusted HR for diabetes incidence was significantly higher in the periodontal disease group, at 1.37 (1.02-1.83), than in the non-periodontal disease group. No significant association was detected in women. When stratified according to sex and obesity status, the non-obese male group showed a significantly higher HR for diabetes incidence in the periodontal disease group (1.75 [1.15-2.66]) compared with the non-periodontal disease group.

Conclusions: This 12-year prospective cohort study demonstrated that periodontal disease significantly increased the risk of diabetes; the association was more pronounced in men, particularly non-obese men.

Supplementary information: The online version contains supplementary material available at 10.1007/s13340-025-00815-z.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Diabetology International
Diabetology International ENDOCRINOLOGY & METABOLISM-
CiteScore
3.90
自引率
4.50%
发文量
42
期刊介绍: Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信