{"title":"使用智能手机IMU传感器进行心肺疾病检测的深度学习框架","authors":"Lorenzo Simone , Luca Miglior , Vincenzo Gervasi , Luca Moroni , Emanuele Vignali , Emanuele Gasparotti , Simona Celi","doi":"10.1016/j.compbiomed.2025.110595","DOIUrl":null,"url":null,"abstract":"<div><div>Respiratory and cardiovascular diseases represent a significant global health burden, underscoring the need for innovative, accessible, and cost-effective screening solutions. This study introduces a clinically grounded framework for the early detection of cardiorespiratory conditions using commodity smartphones equipped with inertial measurement unit sensors. The proposed method leverages accelerometer and gyroscope data collected under a standardized protocol from five distinct thoracoabdominal regions, enabling the acquisition of respiratory kinematics through non-invasive, low-cost technology suitable for remote health monitoring—particularly in resource-limited settings or during pandemic outbreaks. A dedicated preprocessing pipeline segments the time series into individual breathing cycles, which are then analyzed using a bidirectional recurrent neural network to perform binary classification between healthy individuals and patients with cardiovascular disease. The non-healthy cohort comprised preoperative patients diagnosed with conditions including valvular insufficiency, coronary artery disease, and aortic aneurysm. The model was trained and validated using leave-one-out cross-validation with Bayesian hyperparameter optimization. Experimental results demonstrated robust classification performance, with an average sensitivity of <span><math><mrow><mn>0</mn><mo>.</mo><mn>81</mn><mo>±</mo><mn>0</mn><mo>.</mo><mn>02</mn></mrow></math></span>, specificity of <span><math><mrow><mn>0</mn><mo>.</mo><mn>82</mn><mo>±</mo><mn>0</mn><mo>.</mo><mn>05</mn></mrow></math></span>, F1 score of <span><math><mrow><mn>0</mn><mo>.</mo><mn>81</mn><mo>±</mo><mn>0</mn><mo>.</mo><mn>02</mn></mrow></math></span>, and accuracy of <span><math><mrow><mn>80</mn><mo>.</mo><mn>2</mn><mtext>%</mtext><mo>±</mo><mn>3</mn><mo>.</mo><mn>9</mn></mrow></math></span>. On an independent set of unseen healthy individuals, the model achieved a true negative rate of <span><math><mrow><mn>74</mn><mo>.</mo><mn>8</mn><mtext>%</mtext><mo>±</mo><mn>4</mn><mo>.</mo><mn>5</mn></mrow></math></span>, confirming its generalization capability. The proposed framework offers a promising avenue for improving public health, enabling remote monitoring, and supporting clinicians in early diagnosis. Future work should focus on expanding the dataset, refining the methodology for long-term monitoring, and assessing its applicability across diverse clinical and at-home settings.</div></div>","PeriodicalId":10578,"journal":{"name":"Computers in biology and medicine","volume":"196 ","pages":"Article 110595"},"PeriodicalIF":7.0000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Deep learning framework for cardiorespiratory disease detection using smartphone IMU sensors\",\"authors\":\"Lorenzo Simone , Luca Miglior , Vincenzo Gervasi , Luca Moroni , Emanuele Vignali , Emanuele Gasparotti , Simona Celi\",\"doi\":\"10.1016/j.compbiomed.2025.110595\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Respiratory and cardiovascular diseases represent a significant global health burden, underscoring the need for innovative, accessible, and cost-effective screening solutions. This study introduces a clinically grounded framework for the early detection of cardiorespiratory conditions using commodity smartphones equipped with inertial measurement unit sensors. The proposed method leverages accelerometer and gyroscope data collected under a standardized protocol from five distinct thoracoabdominal regions, enabling the acquisition of respiratory kinematics through non-invasive, low-cost technology suitable for remote health monitoring—particularly in resource-limited settings or during pandemic outbreaks. A dedicated preprocessing pipeline segments the time series into individual breathing cycles, which are then analyzed using a bidirectional recurrent neural network to perform binary classification between healthy individuals and patients with cardiovascular disease. The non-healthy cohort comprised preoperative patients diagnosed with conditions including valvular insufficiency, coronary artery disease, and aortic aneurysm. The model was trained and validated using leave-one-out cross-validation with Bayesian hyperparameter optimization. Experimental results demonstrated robust classification performance, with an average sensitivity of <span><math><mrow><mn>0</mn><mo>.</mo><mn>81</mn><mo>±</mo><mn>0</mn><mo>.</mo><mn>02</mn></mrow></math></span>, specificity of <span><math><mrow><mn>0</mn><mo>.</mo><mn>82</mn><mo>±</mo><mn>0</mn><mo>.</mo><mn>05</mn></mrow></math></span>, F1 score of <span><math><mrow><mn>0</mn><mo>.</mo><mn>81</mn><mo>±</mo><mn>0</mn><mo>.</mo><mn>02</mn></mrow></math></span>, and accuracy of <span><math><mrow><mn>80</mn><mo>.</mo><mn>2</mn><mtext>%</mtext><mo>±</mo><mn>3</mn><mo>.</mo><mn>9</mn></mrow></math></span>. On an independent set of unseen healthy individuals, the model achieved a true negative rate of <span><math><mrow><mn>74</mn><mo>.</mo><mn>8</mn><mtext>%</mtext><mo>±</mo><mn>4</mn><mo>.</mo><mn>5</mn></mrow></math></span>, confirming its generalization capability. The proposed framework offers a promising avenue for improving public health, enabling remote monitoring, and supporting clinicians in early diagnosis. Future work should focus on expanding the dataset, refining the methodology for long-term monitoring, and assessing its applicability across diverse clinical and at-home settings.</div></div>\",\"PeriodicalId\":10578,\"journal\":{\"name\":\"Computers in biology and medicine\",\"volume\":\"196 \",\"pages\":\"Article 110595\"},\"PeriodicalIF\":7.0000,\"publicationDate\":\"2025-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computers in biology and medicine\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0010482525009461\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computers in biology and medicine","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010482525009461","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
Deep learning framework for cardiorespiratory disease detection using smartphone IMU sensors
Respiratory and cardiovascular diseases represent a significant global health burden, underscoring the need for innovative, accessible, and cost-effective screening solutions. This study introduces a clinically grounded framework for the early detection of cardiorespiratory conditions using commodity smartphones equipped with inertial measurement unit sensors. The proposed method leverages accelerometer and gyroscope data collected under a standardized protocol from five distinct thoracoabdominal regions, enabling the acquisition of respiratory kinematics through non-invasive, low-cost technology suitable for remote health monitoring—particularly in resource-limited settings or during pandemic outbreaks. A dedicated preprocessing pipeline segments the time series into individual breathing cycles, which are then analyzed using a bidirectional recurrent neural network to perform binary classification between healthy individuals and patients with cardiovascular disease. The non-healthy cohort comprised preoperative patients diagnosed with conditions including valvular insufficiency, coronary artery disease, and aortic aneurysm. The model was trained and validated using leave-one-out cross-validation with Bayesian hyperparameter optimization. Experimental results demonstrated robust classification performance, with an average sensitivity of , specificity of , F1 score of , and accuracy of . On an independent set of unseen healthy individuals, the model achieved a true negative rate of , confirming its generalization capability. The proposed framework offers a promising avenue for improving public health, enabling remote monitoring, and supporting clinicians in early diagnosis. Future work should focus on expanding the dataset, refining the methodology for long-term monitoring, and assessing its applicability across diverse clinical and at-home settings.
期刊介绍:
Computers in Biology and Medicine is an international forum for sharing groundbreaking advancements in the use of computers in bioscience and medicine. This journal serves as a medium for communicating essential research, instruction, ideas, and information regarding the rapidly evolving field of computer applications in these domains. By encouraging the exchange of knowledge, we aim to facilitate progress and innovation in the utilization of computers in biology and medicine.