V Wielandt, F Verdugo-Paiva, J F Oyarzo, Z Iglesias-Ibernia, E Saro-Piaya, E Vázquez-Delgado
{"title":"探讨无关节置换术富血小板血浆治疗颞下颌关节退行性疾病的疗效和安全性：一项系统回顾和荟萃分析。","authors":"V Wielandt, F Verdugo-Paiva, J F Oyarzo, Z Iglesias-Ibernia, E Saro-Piaya, E Vázquez-Delgado","doi":"10.1080/08869634.2025.2521563","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Temporomandibular joint degenerative disease (TMJ-DJD) is a progressive disorder marked by cartilage loss, pain, and dysfunction. This systematic review aimed to evaluate the efficacy and safety of platelet-rich plasma (PRP) injections without arthrocentesis in adults with TMJ-DJD.</p><p><strong>Materials and methods: </strong>Following PRISMA guidelines (PROSPERO: CRD42020183384), we included randomized controlled trials (RCTs) assessing PRP in adults with TMJ-DJD. Searches were conducted in six databases up to June 2024. Two reviewers independently selected studies, extracted data, and assessed bias. Meta-analyses and GRADE evaluations were performed.</p><p><strong>Results: </strong>Six RCTs were included. PRP showed comparable effects to arthrocentesis and arthrocentesis + PRP in reducing pain and improving mouth opening. At 3 months, PRP may offer greater pain relief than hyaluronic acid. No trials assessed quality of life. Evidence certainty ranged from moderate to low.</p><p><strong>Conclusions: </strong>PRP appears to be a safe and potentially effective treatment for TMJ-DJD, though further high-quality studies are needed.</p>","PeriodicalId":56318,"journal":{"name":"Cranio-The Journal of Craniomandibular & Sleep Practice","volume":" ","pages":"1-22"},"PeriodicalIF":2.0000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the efficacy and safety of platelet-rich plasma without arthrocentesis in temporomandibular joint degenerative disease treatment: A systematic review and meta-analysis.\",\"authors\":\"V Wielandt, F Verdugo-Paiva, J F Oyarzo, Z Iglesias-Ibernia, E Saro-Piaya, E Vázquez-Delgado\",\"doi\":\"10.1080/08869634.2025.2521563\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Temporomandibular joint degenerative disease (TMJ-DJD) is a progressive disorder marked by cartilage loss, pain, and dysfunction. This systematic review aimed to evaluate the efficacy and safety of platelet-rich plasma (PRP) injections without arthrocentesis in adults with TMJ-DJD.</p><p><strong>Materials and methods: </strong>Following PRISMA guidelines (PROSPERO: CRD42020183384), we included randomized controlled trials (RCTs) assessing PRP in adults with TMJ-DJD. Searches were conducted in six databases up to June 2024. Two reviewers independently selected studies, extracted data, and assessed bias. Meta-analyses and GRADE evaluations were performed.</p><p><strong>Results: </strong>Six RCTs were included. PRP showed comparable effects to arthrocentesis and arthrocentesis + PRP in reducing pain and improving mouth opening. At 3 months, PRP may offer greater pain relief than hyaluronic acid. No trials assessed quality of life. Evidence certainty ranged from moderate to low.</p><p><strong>Conclusions: </strong>PRP appears to be a safe and potentially effective treatment for TMJ-DJD, though further high-quality studies are needed.</p>\",\"PeriodicalId\":56318,\"journal\":{\"name\":\"Cranio-The Journal of Craniomandibular & Sleep Practice\",\"volume\":\" \",\"pages\":\"1-22\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cranio-The Journal of Craniomandibular & Sleep Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/08869634.2025.2521563\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cranio-The Journal of Craniomandibular & Sleep Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/08869634.2025.2521563","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Exploring the efficacy and safety of platelet-rich plasma without arthrocentesis in temporomandibular joint degenerative disease treatment: A systematic review and meta-analysis.
Objective: Temporomandibular joint degenerative disease (TMJ-DJD) is a progressive disorder marked by cartilage loss, pain, and dysfunction. This systematic review aimed to evaluate the efficacy and safety of platelet-rich plasma (PRP) injections without arthrocentesis in adults with TMJ-DJD.
Materials and methods: Following PRISMA guidelines (PROSPERO: CRD42020183384), we included randomized controlled trials (RCTs) assessing PRP in adults with TMJ-DJD. Searches were conducted in six databases up to June 2024. Two reviewers independently selected studies, extracted data, and assessed bias. Meta-analyses and GRADE evaluations were performed.
Results: Six RCTs were included. PRP showed comparable effects to arthrocentesis and arthrocentesis + PRP in reducing pain and improving mouth opening. At 3 months, PRP may offer greater pain relief than hyaluronic acid. No trials assessed quality of life. Evidence certainty ranged from moderate to low.
Conclusions: PRP appears to be a safe and potentially effective treatment for TMJ-DJD, though further high-quality studies are needed.
期刊介绍：
CRANIO: The Journal of Craniomandibular & Sleep Practice is the oldest and largest journal in the world devoted to temporomandibular disorders, and now also includes articles on all aspects of sleep medicine. The Journal is multidisciplinary in its scope, with editorial board members from all areas of medicine and dentistry, including general dentists, oral surgeons, orthopaedists, radiologists, chiropractors, professors and behavioural scientists, physical therapists, acupuncturists, osteopathic and ear, nose and throat physicians.
CRANIO publishes commendable works from outstanding researchers and clinicians in their respective fields. The multidisciplinary format allows individuals practicing with a TMD emphasis to stay abreast of related disciplines, as each issue presents multiple topics from overlapping areas of interest.
CRANIO''s current readership (thousands) is comprised primarily of dentists; however, many physicians, physical therapists, chiropractors, osteopathic physicians and other related specialists subscribe and contribute to the Journal.
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