D A Evsyukov, Yu T Tsukanov, V P Dorofeeva, I O Snitko, M Kh Alikberov, A Yu Tsukanov
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引用次数: 0
摘要
目的：建立犬慢性静脉曲张模型。材料与方法：选取15只体重15000 ~ 17000 g的性成熟杂种未阉割公犬，随机分为3组：ⅰ组（对照组）-肌注人绒毛膜促性腺激素200 U/kg和孕酮1% 0.1 ml/kg；II组-己甾醇0.09 mg/kg和孕酮1% 0.1 ml /kg肌内注射；III组-黄体酮1% 0.1 ml /kg肌注。术前1天给药。然后，我们在联合麻醉下狭窄大腿上三分之一的股静脉。术后及术后6天继续肌注上述药物。术前1天、术后10天和30天分别监测超声参数和实验室数据（白细胞、CRP、IL-6）。结果：股静脉狭窄1 / 2合并孕酮和雌激素可导致分阶段发展的静脉曲张疾病，并具有持续不可逆的表现。与第1组和第3组不同，这种组合与炎症反应的关联较小。结论：建立了一种慢性实验静脉曲张模型的方法。
Objective: To create a method for modeling of varicose veins in dogs in a chronic experiment.
Material and methods: The experiment was carried out on 15 sexually mature mongrel uncastrated male dogs weighing 15.000-17.000 g divided into 3 groups: group I (control) - human chorionic gonadotropin 200 U/kg and progesterone 1% 0.1 ml/kg intramuscularly; group II - hexestrol 0.09 mg/kg and progesterone 1% 0.1 ml /kg intramuscularly; group III - progesterone 1% 0.1 ml /kg intramuscularly. The drugs were administered 1 day before surgery. Then, we narrowed femoral vein in the upper third of the thigh under combined anesthesia. Intramuscular administration of the above-mentioned drugs was continued after surgery and for the next 6 days. Monitoring of ultrasound parameters and laboratory data (leukocytes, CRP, IL-6) was performed 1 day before surgery, after 10 and 30 days.
Results: Femoral vein narrowing by ½ combined with progesterone and estrogen leads to staged development of varicose disease with persistent irreversible manifestations. Unlike groups 1 and 3, this combination is less associated with inflammatory response.
Conclusion: A method for modeling of varicose veins in a chronic experiment was created.
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