双相样品空间分辨13C核磁共振波谱在定向介质分子分析中的应用。

IF 1.9 3区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Magnetic Resonance in Chemistry Pub Date : 2025-07-01 DOI:10.1002/mrc.70003

Thomas Julien, Boris Gouilleux, Michael Reggelin, Philippe Lesot

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引用次数: 0

摘要

溶性、手性双相体系和空间分辨2H nD核磁共振波谱的使用最近已被开创。化学。Lett. 2024)作为一种原始工具，能够使用单个核磁共振样品提供两组独立的各向异性光谱数据。在这项工作中，我们探索了空间定位13C和13C-{1H} 1D和2D NMR实验（CLIP-HSQC, ch -resolved）结合由多肽和聚乙炔手性聚合物（PBLG和L-MSP）组成的双相样品的分析潜力。这种原始的各向异性方法的有效性在布洛芬等手性分子的对映体分析以及多立体中心手性化合物（(+)-IPC）的构型和三维结构分析的背景下得到了探索。

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Spatially Resolved ¹³C NMR Spectroscopy in Bimesophasic Samples Applied to Molecular Analysis in Orienting Media.

The use of lyotropic, chiral bimesophasic systems and spatially resolved ²H nD NMR spectroscopy has recently been pioneered (J. Phys. Chem. Lett. 2024) as an original tool capable of providing two independent sets of anisotropic spectral data with a single NMR sample. In this work, we explore the analytical potential of spatially localized ¹³C and ¹³C-{¹H} 1D and 2D NMR experiments (CLIP-HSQC, T_CH-resolved) combined with bimesophasic samples composed of polypeptide and polyacetylene chiral polymers (PBLG and L-MSP). The effectiveness of this original anisotropic approach is being explored in the context of the enantiomeric analysis of chiral molecules such as ibuprofen, as well as the configurational and 3D structural analysis of multi-stereocenter chiral compounds (case of (+)-IPC).

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来源期刊

Magnetic Resonance in Chemistry 化学-光谱学

CiteScore

4.70

自引率

10.00%

发文量

审稿时长

1 months

期刊介绍： MRC is devoted to the rapid publication of papers which are concerned with the development of magnetic resonance techniques, or in which the application of such techniques plays a pivotal part. Contributions from scientists working in all areas of NMR, ESR and NQR are invited, and papers describing applications in all branches of chemistry, structural biology and materials chemistry are published. The journal is of particular interest not only to scientists working in academic research, but also those working in commercial organisations who need to keep up-to-date with the latest practical applications of magnetic resonance techniques.