治疗后血清CXCL10水平对直接作用抗病毒治疗后慢性丙型肝炎病毒感染代偿和失代偿肝硬化患者的生存分层

IF 6.9 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Takanori Suzuki, Kentaro Matsuura, Yuki Tahata, Hayato Hikita, Ryotaro Sakamori, Norifumi Kawada, Nobuyuki Enomoto, Daiki Miki, Hiroshi Yatsuhashi, Hidekatsu Kuroda, Taro Yamashita, Hitoshi Yoshiji, Masayuki Kurosaki, Seiichi Mawatari, Hisamitsu Miyaaki, Yasuhiro Asahina, Yoichi Hiasa, Satoshi Mochida, Yasunari Nakamoto, Taro Takami, Takahiro Kodama, Tomohide Tatsumi, Tetsuo Takehara
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引用次数: 0

摘要

目的:研究血清CXCL10水平对丙型肝炎病毒(HCV)感染的代偿性和失代偿性肝硬化(cLC和dLC)患者在直接作用抗病毒药物(DAA)治疗后预后的预测作用。方法:这项全国性的多中心研究纳入了212例hcv相关的LC患者,包括113例cLC和99例dLC患者,接受DAA治疗,并保存了血清样本。在治疗前(CXCL10前)和治疗后(治疗结束后12或24周:EOT12W或EOT24W) (CXCL10后)测定血清CXCL10水平。我们评估了这些水平与肝移植(LT)游离总生存期(OS)和临床结果之间的关系。结果:在观察期内(中位时间:37个月),27例患者发生dLC事件,20例死亡。dLC患者cxcl10后水平显著高于cLC患者(P = 0.006),死亡患者的cxcl10后水平显著高于存活患者(P结论:血清cxcl10后水平与hcv相关LC患者的生存独立相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Posttreatment serum CXCL10 level stratifies survival in compensated and decompensated cirrhotic patients due to chronic hepatitis C virus infection after direct-acting antiviral therapy.

Aim: We investigated the usefulness of serum CXCL10 levels for predicting prognosis in hepatitis C virus (HCV)-infected patients with compensated and decompensated cirrhosis (cLC and dLC) after direct-acting antiviral (DAA) therapy.

Methods: This nationwide multicenter study enrolled 212 HCV-associated LC patients, consisting of 113 cLC and 99 dLC patients, receiving DAA therapy, who had preserved serum samples. Serum CXCL10 levels were measured at pretreatment (pre-CXCL10) and posttreatment (12 or 24 weeks after the end of treatment: EOT12W or EOT24W) (post-CXCL10). We evaluated the relationship between these levels and liver transplantation (LT)-free overall survival (OS) and clinical outcomes.

Results: During the observational period (median: 37 months), 27 patients developed dLC events and 20 died. The post-CXCL10 levels were significantly higher in dLC than in cLC (P = 0.006) and among patients who died than those who survived (P < 0.001). The cutoff value of serum post-CXCL10 level for discriminating the occurrence of death (345 pg/mL) could predict LT-free OS in groups of all, cLC, and dLC patients (P < 0.001, P = 0.007, and P < 0.001, respectively). Multivariate analysis on factors associated with LT-free OS demonstrated that age (HR 1.076; P = 0.013), Child-Pugh score at EOT12W (HR 1.575; P = 0.009), and serum post-CXCL10 level (HR 1.003; P = 0.001) were independent factors.

Conclusions: The serum post-CXCL10 level was independently related to survival in HCV-associated LC patients.

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来源期刊
Journal of Gastroenterology
Journal of Gastroenterology 医学-胃肠肝病学
CiteScore
12.20
自引率
1.60%
发文量
99
审稿时长
4-8 weeks
期刊介绍: The Journal of Gastroenterology, which is the official publication of the Japanese Society of Gastroenterology, publishes Original Articles (Alimentary Tract/Liver, Pancreas, and Biliary Tract), Review Articles, Letters to the Editors and other articles on all aspects of the field of gastroenterology. Significant contributions relating to basic research, theory, and practice are welcomed. These publications are designed to disseminate knowledge in this field to a worldwide audience, and accordingly, its editorial board has an international membership.
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