medicX-KG:药师药品信息需求知识图谱。

IF 1.6 3区 工程技术 Q3 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Lizzy Farrugia, Lilian M Azzopardi, Jeremy Debattista, Charlie Abela
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引用次数: 0

摘要

药剂师的角色正在从药物调剂发展到在多学科医疗团队中提供全面的药物服务。这一转变的核心是获得由强大的数据集成支持的准确、最新的药品信息。利用人工智能和语义技术,知识图(KGs)可以揭示隐藏的关系,并实现数据驱动的决策。本文介绍了medicX-KG,一个支持临床和监管决策的面向药剂师的知识图谱。它构成了更广泛的medicX平台的语义层,为可预测和可解释的药房服务提供支持。medicX-KG整合了来自三个来源的数据,包括英国国家处方集(BNF)、药品银行和马耳他药品管理局(MMA),解决了马耳他的监管环境,并将欧洲药品管理局与部分英国供应依赖相结合。KG解决了缺乏统一的国家药物储存库的问题,减少了药剂师对分散来源的依赖。它的设计是通过与执业药剂师的访谈来确保现实世界的适用性。我们详细介绍了KG的构建,包括数据提取、本体设计和语义映射。评估表明,medicX-KG有效地支持关于药物可用性、相互作用、不良反应和治疗类别的查询。局限性,包括缺少详细的剂量编码和实时更新,讨论了未来增强的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
medicX-KG: a knowledge graph for pharmacists' drug information needs.

The role of pharmacists is evolving from medicine dispensing to delivering comprehensive pharmaceutical services within multidisciplinary healthcare teams. Central to this shift is access to accurate, up-to-date medicinal product information supported by robust data integration. Leveraging artificial intelligence and semantic technologies, Knowledge Graphs (KGs) uncover hidden relationships and enable data-driven decision-making. This paper presents medicX-KG, a pharmacist-oriented knowledge graph supporting clinical and regulatory decisions. It forms the semantic layer of the broader medicX platform, powering predictive and explainable pharmacy services. medicX-KG integrates data from three sources, including, the British National Formulary (BNF), DrugBank, and the Malta Medicines Authority (MMA) that addresses Malta's regulatory landscape and combines European Medicines Agency alignment with partial UK supply dependence. The KG tackles the absence of a unified national drug repository, reducing pharmacists' reliance on fragmented sources. Its design was informed by interviews with practising pharmacists to ensure real-world applicability. We detail the KG's construction, including data extraction, ontology design, and semantic mapping. Evaluation demonstrates that medicX-KG effectively supports queries about drug availability, interactions, adverse reactions, and therapeutic classes. Limitations, including missing detailed dosage encoding and real-time updates, are discussed alongside directions for future enhancements.

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来源期刊
Journal of Biomedical Semantics
Journal of Biomedical Semantics MATHEMATICAL & COMPUTATIONAL BIOLOGY-
CiteScore
4.20
自引率
5.30%
发文量
28
审稿时长
30 weeks
期刊介绍: Journal of Biomedical Semantics addresses issues of semantic enrichment and semantic processing in the biomedical domain. The scope of the journal covers two main areas: Infrastructure for biomedical semantics: focusing on semantic resources and repositories, meta-data management and resource description, knowledge representation and semantic frameworks, the Biomedical Semantic Web, and semantic interoperability. Semantic mining, annotation, and analysis: focusing on approaches and applications of semantic resources; and tools for investigation, reasoning, prediction, and discoveries in biomedicine.
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