m6A甲基化：解开精神障碍的新钥匙。

IF 4.5 2区医学 Q1 CLINICAL NEUROLOGY

International Journal of Neuropsychopharmacology Pub Date : 2025-07-01 DOI:10.1093/ijnp/pyaf044

Yinuo Wang, Xiaobing Li, Min Liu, Xiaoxu Xu, Yue Ma, Yang Luo, Yue Wang

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引用次数: 0

摘要

在哺乳动物细胞中已经发现了100多种类型的RNA修饰，其中n6 -甲基腺苷（m6A）修饰最为普遍。这种可逆和动态的修饰涉及甲基转移酶、去甲基化酶和解读蛋白。神经系统中m6a相关调节蛋白的异常表达显著影响神经元生理，导致抑郁症、自闭症谱系障碍和精神分裂症等精神障碍。本文综述了m6A甲基化在精神障碍发病机制中的作用，并强调了其作为生物标志物和治疗靶点的潜力，为今后的研究和临床干预提供综合参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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m6A Methylation: A Novel Key to Unlocking Mental Disorders.

More than 100 types of RNA modifications have been identified in mammalian cells, among which N6-methyladenosine (m6A) is the most prevalent. This reversible and dynamic modification involves methyltransferases, demethylases, and reader proteins. Aberrant expression of m6A-related regulatory proteins in the nervous system significantly impacts neuronal physiology, contributing to mental disorders such as depression, autism spectrum disorder, and schizophrenia. This review summarizes the role of m6A methylation in the pathogenesis of mental disorders and highlights its potential as a biomarker and therapeutic target, providing a comprehensive reference for future research and clinical interventions.

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来源期刊

International Journal of Neuropsychopharmacology 医学-精神病学

CiteScore

8.40

自引率

2.10%

发文量

230

审稿时长

4-8 weeks

期刊介绍： The central focus of the journal is on research that advances understanding of existing and new neuropsychopharmacological agents including their mode of action and clinical application or provides insights into the biological basis of psychiatric disorders and thereby advances their pharmacological treatment. Such research may derive from the full spectrum of biological and psychological fields of inquiry encompassing classical and novel techniques in neuropsychopharmacology as well as strategies such as neuroimaging, genetics, psychoneuroendocrinology and neuropsychology.