非小细胞肺癌合并HBV和EBV感染患者的免疫检查点抑制剂相关性结肠炎1例报告

IF 2.3 4区医学 Q3 IMMUNOLOGY

Immunotherapy Pub Date : 2025-06-01 Epub Date: 2025-07-01 DOI:10.1080/1750743X.2025.2527023

Chao Han, Sujuan Xi, Te Shi, Haiyan Yue

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引用次数: 0

摘要

结肠炎是使用免疫检查点抑制剂（ICI）治疗的患者常见的不良事件。此外，在ICI治疗期间，病毒感染会增加风险。皮质类固醇是治疗ici相关性结肠炎的基石。我们在此报告一个病例，包括详细的内镜和病理结果，诊断为晚期非小细胞肺癌的患者，他同时感染HBV和EBV，并在口服甲基强的松龙治疗后表现出显著的改善。鉴于ICI的广泛使用，医生应警惕各种不良事件，并且在使用ICI治疗期间应密切监测患者。内镜和病理评估对ici相关性结肠炎管理的见解。

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Immune checkpoint inhibitor-related colitis in a patient with non-small cell lung cancer co-infected with HBV and EBV: a case report.

Colitis is a common adverse event in patients treated with immune checkpoint inhibitor (ICI). Additionally, virus infections pose an increased risk during ICI therapy. Corticosteroids is the cornerstone in treatment for ICI-related colitis. We herein report a case that includes detailed endoscopic and pathological findings of a patient diagnosed with advanced non-small cell lung cancer who was co-infected with HBV and EBV and demonstrated significant improvement after treatment with oral methylprednisolone. Given the widespread use of ICI, physicians should be vigilant regarding various adverse events, and patients should be monitored closely during treatment with ICI. Endoscopic and pathological evaluation insights into the management of ICI-related colitis.

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来源期刊

Immunotherapy 医学-免疫学

CiteScore

5.00

自引率

3.60%

发文量

113

审稿时长

6-12 weeks

期刊介绍： Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field. Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.