{"title":"基于多模态图像的个体化三维剂量计算方法在前列腺癌伴颅骨转移剂量学评估中的蒙特卡罗模拟研究。","authors":"Feng Tian, Huan Liu, Yingying Gu, Dandan Zhang, Lijun Tang","doi":"10.1186/s40658-025-00781-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The nuclear medicine treatment based on <sup>177</sup>Lu-PSMA-617 has achieved excellent therapeutic effects on Prostate cancer (PCa), but there is a lack of three-dimensional dosimetry analysis of organs at risk (OARs) and distant metastatic lesions.</p><p><strong>Results: </strong>This work establishes an accurate and personalized three-dimensional dose calculation method based on Monte Carlo simulation and multi-modal images of PCa patients with skull metastasis, and analyzes the three-dimensional dose distribution of metastatic lesions and OARs in the brain. Results show that due to the targeting characteristics of <sup>177</sup>Lu-PSMA-617, metastatic brain lesions of all patients can receive high radiation doses with the average dose of 0.05 mGy/MBq, and the dose distribution are relatively uniform with the average homogeneity index of 1.23. In addition, the radiation dose received by most OARs are much lower than that of metastatic lesions, but for parotid glands, the dose deposited are only 3.99 times less than that of metastatic lesions due to the high absorption of <sup>177</sup>Lu-PSMA-617.</p><p><strong>Conclusion: </strong>Therefore, it is necessary to clarify the three-dimensional dose distribution of OARs and metastatic lesions, so as to optimize the activity injected and achieve the precise killing of metastatic lesions and protection of OARs.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"12 1","pages":"59"},"PeriodicalIF":3.0000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214214/pdf/","citationCount":"0","resultStr":"{\"title\":\"Personalized three-dimensional dose calculation method based on multi-modal images in dosimetry assessment of prostate cancer with skull metastasis: a Monte Carlo simulation study.\",\"authors\":\"Feng Tian, Huan Liu, Yingying Gu, Dandan Zhang, Lijun Tang\",\"doi\":\"10.1186/s40658-025-00781-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The nuclear medicine treatment based on <sup>177</sup>Lu-PSMA-617 has achieved excellent therapeutic effects on Prostate cancer (PCa), but there is a lack of three-dimensional dosimetry analysis of organs at risk (OARs) and distant metastatic lesions.</p><p><strong>Results: </strong>This work establishes an accurate and personalized three-dimensional dose calculation method based on Monte Carlo simulation and multi-modal images of PCa patients with skull metastasis, and analyzes the three-dimensional dose distribution of metastatic lesions and OARs in the brain. Results show that due to the targeting characteristics of <sup>177</sup>Lu-PSMA-617, metastatic brain lesions of all patients can receive high radiation doses with the average dose of 0.05 mGy/MBq, and the dose distribution are relatively uniform with the average homogeneity index of 1.23. In addition, the radiation dose received by most OARs are much lower than that of metastatic lesions, but for parotid glands, the dose deposited are only 3.99 times less than that of metastatic lesions due to the high absorption of <sup>177</sup>Lu-PSMA-617.</p><p><strong>Conclusion: </strong>Therefore, it is necessary to clarify the three-dimensional dose distribution of OARs and metastatic lesions, so as to optimize the activity injected and achieve the precise killing of metastatic lesions and protection of OARs.</p>\",\"PeriodicalId\":11559,\"journal\":{\"name\":\"EJNMMI Physics\",\"volume\":\"12 1\",\"pages\":\"59\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214214/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EJNMMI Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s40658-025-00781-0\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EJNMMI Physics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40658-025-00781-0","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Personalized three-dimensional dose calculation method based on multi-modal images in dosimetry assessment of prostate cancer with skull metastasis: a Monte Carlo simulation study.
Background: The nuclear medicine treatment based on 177Lu-PSMA-617 has achieved excellent therapeutic effects on Prostate cancer (PCa), but there is a lack of three-dimensional dosimetry analysis of organs at risk (OARs) and distant metastatic lesions.
Results: This work establishes an accurate and personalized three-dimensional dose calculation method based on Monte Carlo simulation and multi-modal images of PCa patients with skull metastasis, and analyzes the three-dimensional dose distribution of metastatic lesions and OARs in the brain. Results show that due to the targeting characteristics of 177Lu-PSMA-617, metastatic brain lesions of all patients can receive high radiation doses with the average dose of 0.05 mGy/MBq, and the dose distribution are relatively uniform with the average homogeneity index of 1.23. In addition, the radiation dose received by most OARs are much lower than that of metastatic lesions, but for parotid glands, the dose deposited are only 3.99 times less than that of metastatic lesions due to the high absorption of 177Lu-PSMA-617.
Conclusion: Therefore, it is necessary to clarify the three-dimensional dose distribution of OARs and metastatic lesions, so as to optimize the activity injected and achieve the precise killing of metastatic lesions and protection of OARs.
期刊介绍:
EJNMMI Physics is an international platform for scientists, users and adopters of nuclear medicine with a particular interest in physics matters. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, this journal has a multi-disciplinary approach and welcomes original materials and studies with a focus on applied physics and mathematics as well as imaging systems engineering and prototyping in nuclear medicine. This includes physics-driven approaches or algorithms supported by physics that foster early clinical adoption of nuclear medicine imaging and therapy.