由多齿席夫碱配体构建的两种新型四核Ni（II）基化合物：结构、抗菌活性和与DNA的相互作用

IF 2.4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Polyhedron Pub Date : 2025-06-25 DOI:10.1016/j.poly.2025.117660

Yan-Hong Li , Dong-Xiao Han , Jia-Tong Liu , Wen-Juan Li , Dong-Ni An , Mei-Hui Yao , Mei-Zhen Ao , Jin-Ling Wang , Ya-Juan Lv , Xiao-Yan Xin , Zhi-Qiang Wang

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引用次数: 0

摘要

利用两种不同的多齿希夫碱配体(H2L1 = （E)-2-（（4-溴-2-（羟甲基）苯基）亚氨基）甲基）-4-甲基苯酚和H3L2 = 6,6′-((1E, 1E)-（（2-羟基丙烷-1,3-二基）双（氮化酰基）双（甲烷基）双（4-溴-2-甲氧基苯酚））与Ni（Ac）₂·4H2O反应，采用溶剂热法合成了两个新的、有趣的四核Ni（II）基化合物：[Ni4(L1)4(C2H5OH)3(H2O)]和[Ni4(L2)2(μ3- ch30)2（CH3OH)2]·2CH3OH(2)）。x射线衍射研究表明，化合物1属于单斜空间群P2/c，化合物2属于单斜空间群c2 /c。化合物1主要含有一个立方体Ni4O4芯，化合物2主要含有一个Ni4O6芯，形成两个有缺陷的立方体结构。测定了配体H2L1、H3L2和化合物1、2对枯草芽孢杆菌、白色念珠菌、大肠杆菌和金黄色葡萄球菌4种细菌的抑菌活性。研究了Ni4化合物1、2与小牛胸腺DNA的相互作用，结果表明化合物1、2主要嵌入小牛胸腺DNA。

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Two novel tetranuclear Ni(II)-based compounds constructed by polydentate Schiff base ligands: Structures, antibacterial activities and interaction with DNA

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Two novel tetranuclear Ni(II)-based compounds constructed by polydentate Schiff base ligands: Structures, antibacterial activities and interaction with DNA

Two new and interesting tetranuclear Ni((II)-based compounds: [Ni₄(L1)₄(C₂H₅OH)₃(H₂O)] (1) and [Ni₄(L2)₂(μ₃-CH₃O)₂(CH₃OH)₂]·2CH₃OH (2) have been synthesized via the solvothermal method by using two different polydentate Schiff base ligands (H₂L1 = (E)-2-(((4-bromo-2-(hydroxymethyl)phenyl)imino)methyl)-4-methylphenol and H₃L2 = 6,6′-((1E,1′E)-((2-hydroxypropane-1,3-diyl)bis(azaneylylidene))bis(methaneylylidene))bis(4-bromo-2-methoxyphenol)) reacting with Ni(Ac)₂·4H₂O. X-ray diffraction studies reveal that compound 1 belongs to monoclinic space group P2/c and compound 2 belongs to monoclinic space group C 2/c. Compound 1 mainly contains a cubane Ni₄O₄ core, while compound 2 mainly contains a Ni₄O₆ core forming two defective cubane structures. The antibacterial activity of the ligand H₂L1, H₃L2 and compounds 1 and 2 against four species of bacteria B. subtilis, C. albicans, E. coli, and S. aureus were tested respectively. The interaction between Ni₄ compounds 1, 2 and calf thymus DNA were studied and the results revealed that compounds 1 and 2 were mainly intercalated with calf thymus DNA.

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来源期刊

Polyhedron 化学-晶体学

CiteScore

4.90

自引率

7.70%

发文量

515

审稿时长

2 months

期刊介绍： Polyhedron publishes original, fundamental, experimental and theoretical work of the highest quality in all the major areas of inorganic chemistry. This includes synthetic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry, and solid-state and materials chemistry. Papers should be significant pieces of work, and all new compounds must be appropriately characterized. The inclusion of single-crystal X-ray structural data is strongly encouraged, but papers reporting only the X-ray structure determination of a single compound will usually not be considered. Papers on solid-state or materials chemistry will be expected to have a significant molecular chemistry component (such as the synthesis and characterization of the molecular precursors and/or a systematic study of the use of different precursors or reaction conditions) or demonstrate a cutting-edge application (for example inorganic materials for energy applications). Papers dealing only with stability constants are not considered.