双烯丙基酰胺的去对称化：催化对映选择性非对映选择性氯环化策略。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-07-01 DOI:10.1021/acs.orglett.5c01865

Yi Yi, Ankush Chakraborty, Xinliang Ding, Arvind Jaganathan, Neil Heberer and Babak Borhan*,

引用次数: 0

摘要

以n -氯酞酰亚胺（NCP）为氯化试剂，（DHQD） 2phal催化双烯丙基酰胺的非对映选择性和对映选择性氯化反应。以高收率（可达99%）、高非对映选择性和优异的对映选择性（可达99% ee）得到了一系列具有三个连续手性中心的氯代恶嗪。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Desymmetrization of Bisallylic Amides: A Catalytic Enantioselective Diastereoselective Chlorocyclization Strategy

(DHQD)₂PHAL-catalyzed diastereoselective and enantioselective chlorocyclization reactions of bisallylic amides were achieved with N-chlorophthalimide (NCP) as the chlorinating reagent. A series of chlorinated oxazines bearing three contiguous chiral centers were obtained in high yields (up to 99%), high diastereoselectivity and excellent enantioselectivity (up to 99% ee).

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.