代谢相关脂肪变性肝病：从分子机制到新疗法

IF 1.4 Q3 GASTROENTEROLOGY & HEPATOLOGY

International Journal of Hepatology Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI:10.1155/ijh/5580454

John Cooper, Parth Patel, Joven Tristeza, Alexander Yang

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引用次数: 0

摘要

代谢性脂肪变性肝病（MASLD）是一个迅速发展的世界性负担，目前是肝移植的主要指征。尽管疾病负担越来越重，但可用的药物治疗方法却很少。MASLD发展的潜在分子机制仍在阐明中。在这篇综述中，我们将总结已知的MASLD发展的分子机制以及过去、现在和未来的药理临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Metabolic-Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel Therapies.

Metabolic-associated steatotic liver disease (MASLD) is a burgeoning worldwide burden and is currently the leading indication for a liver transplant. Despite the growing burden of disease, there are few pharmacological treatments available. The underlying molecular mechanisms of the development of MASLD are still being elucidated. In this review, we will summarize the known molecular mechanisms in the development of MASLD along with past, current, and future pharmacologic clinical trials.

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来源期刊

International Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： International Journal of Hepatology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the medical, surgical, pathological, biochemical, and physiological aspects of hepatology, as well as the management of disorders affecting the liver, gallbladder, biliary tree, and pancreas.