SCI人类和动物模型中血清骨生物标志物的系统搜索和修正e-Delphi共识:方法论。

IF 2.4 Q1 REHABILITATION
Topics in Spinal Cord Injury Rehabilitation Pub Date : 2025-01-01 Epub Date: 2025-06-19 DOI:10.46292/sci24-00042
Philemon Tsang, Matthew Cleland, Matheus Wiest, Kristine C Cowley, Emily Newton, Eleni Patsakos, Matteo Ponzano, Lora Giangregorio, Saina Aliabadi, Katrina Armstrong, Karim Fouad, David Magnuson, B Catharine Craven
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引用次数: 0

摘要

脊髓损伤(SCI)后骨密度和结构的骨代谢恶化的改变是复杂和多因素的:机械卸载、成骨细胞活性受损、激素水平改变和局部血流量共同增加下肢骨折的发病率和死亡率。骨生物标志物对于检测疾病、确定候选治疗方法、监测治疗效果和量化骨折风险至关重要。目的:本研究旨在综合动物和人类脊髓损伤模型中血清和血浆骨生物标志物的现有文献,并就其在整个转译连续体中的适用性达成共识。方法:系统检索;排除4731项研究,共125项研究用于数据提取。数据由一个跨学科专家小组审查。通过改进的e-Delphi过程,对14种血清骨生物标志物在人类和动物模型以及整个转化连续体中的适用性进行了反复的共识声明。结果:共识过程强调了解释动物和人类模型的挑战,强调了方法严谨性和标准化生物标志物报告的必要性。考虑到生物标志物的日变化和模型选择(横断与剪切),强调了SCI研究的复杂性。考虑到大多数人类数据来自雄性,动物数据来自雌性,限制包括定义“成年”啮齿动物,缺乏与生物标志物性别相关的差异及其解释的数据。结论:共识声明提供了指导,解决了生物标志物报告和解释方面的差距,促进了标准化方案和检测试剂盒的使用,并强调了推进科学发现和促进知识转化的跨学科方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Systematic Search and Modified e-Delphi Consensus for Serum Bone Biomarkers in Humans and Animal Models with SCI: Methodology.

Introduction: Alterations to bone metabolism deteriorations in bone density and architecture after spinal cord injury (SCI) are complex and multifactorial: mechanical unloading, impaired osteoblast activity, altered hormone levels, and regional blood flow combine to increase lower extremity fracture incidence and mortality. Bone biomarkers are vital to detect disease, identify candidate therapies, monitor therapy effectiveness, and quantify fracture risk.

Objectives: This study aimed to synthesize available literature on serum and plasma bone biomarkers in both animal and human SCI models and to generate consensus regarding their appropriateness for use across the translational continuum.

Methods: A systematic search was conducted; 4731 studies were excluded, yielding 125 studies for data extraction. Data were reviewed by an interdisciplinary panel of experts. Through a modified e-Delphi process, consensus statements were iteratively developed regarding the appropriateness of 14 serum bone biomarkers in human and animal models and across the translational continuum.

Results: The consensus process highlighted challenges in interpreting animal and human models, emphasizing the need for methodological rigor and standardized biomarker reporting. Consideration of diurnal variations in biomarkers and model selection (transection vs. clip) underscored the complexity of SCI research. Limitations included defining "adult" rodents and lack of data on sex-related differences in biomarkers and their interpretation, given most human data were obtained from males and animal data from females.

Conclusion: The consensus statements provide guidance, address gaps in reporting and interpretation of biomarkers, promote use of standardized protocols and assay kits, and emphasize interdisciplinary approaches to advancing scientific discovery and facilitating knowledge translation.

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来源期刊
CiteScore
3.20
自引率
3.40%
发文量
33
期刊介绍: Now in our 22nd year as the leading interdisciplinary journal of SCI rehabilitation techniques and care. TSCIR is peer-reviewed, practical, and features one key topic per issue. Published topics include: mobility, sexuality, genitourinary, functional assessment, skin care, psychosocial, high tetraplegia, physical activity, pediatric, FES, sci/tbi, electronic medicine, orthotics, secondary conditions, research, aging, legal issues, women & sci, pain, environmental effects, life care planning
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