线粒体自噬:脊髓损伤病理生理和治疗的关键调节因子。

IF 5.9 2区 医学 Q2 CELL BIOLOGY
Neural Regeneration Research Pub Date : 2026-04-01 Epub Date: 2025-03-25 DOI:10.4103/NRR.NRR-D-24-01029
Qiuyang Gu, Shengye Yuan, Yumei An, Wenyue Sun, Mingyuan Xu, Mengchun Xue, Xianzhe Li, Chao Liu, Haiyan Shan, Mingyang Zhang
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引用次数: 0

摘要

线粒体自噬与继发性脊髓损伤的发病机制密切相关。线粒体自噬异常可能是继发性脊髓损伤的重要原因,可导致三磷酸腺苷生成受损、离子失衡、活性氧生成过多、神经炎症和神经元细胞死亡。因此,在治疗脊髓损伤时,维持适当的线粒体自噬平衡是至关重要的,因为线粒体自噬过多和不足都会阻碍恢复。本文就脊髓损伤的病理变化、线粒体自噬的发生机制以及线粒体自噬与脊髓损伤的直接和间接关系作一综述。我们还考虑针对线粒体自噬治疗脊髓损伤的治疗方法,包括正在进行的临床试验和其他创新疗法,如使用干细胞、纳米材料和小分子聚合物。最后,我们强调了该领域目前面临的挑战,并提出了未来研究的潜在方向。本文综述的目的是为今后针对线粒体自噬治疗脊髓损伤的研究提供理论参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mitophagy: A key regulator in the pathophysiology and treatment of spinal cord injury.

Mitophagy is closely associated with the pathogenesis of secondary spinal cord injury. Abnormal mitophagy may contribute significantly to secondary spinal cord injury, leading to the impaired production of adenosine triphosphate, ion imbalance, the excessive production of reactive oxygen species, neuroinflammation, and neuronal cell death. Therefore, maintaining an appropriate balance of mitophagy is crucial when treating spinal cord injury, as both excessive and insufficient mitophagy can impede recovery. In this review, we summarize the pathological changes associated with spinal cord injury, the mechanisms of mitophagy, and the direct and indirect relationships between mitophagy and spinal cord injury. We also consider therapeutic approaches that target mitophagy for the treatment of spinal cord injury, including ongoing clinical trials and other innovative therapies, such as use of stem cells, nanomaterials, and small molecule polymers. Finally, we highlight the current challenges facing this field and suggest potential directions for future research. The aim of our review is to provide a theoretical reference for future studies targeting mitophagy in the treatment of spinal cord injury.

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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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