Ross A Okazaki, Syed H Rizvi, Rachael Lyons, Leili Behrooz, Naomi M Hamburg
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Vascular Dysfunction in Diabetes and Pharmacotherapeutic Opportunities: A Focus on Endothelial Cell Health.
Endothelial dysfunction contributes to the pathogenesis and progression of type 2 diabetes mellitus (T2DM) and cardiovascular disease. Endothelial dysfunction in T2DM has been studied extensively using in experimental models and human studies using non-invasive assessment of vasomotor function. Recent work has also demonstrated the feasibility of translational research using freshly isolated human endothelial cells (FIHECs) to uncover novel mechanisms of endothelial dysfunction in T2DM. This review provides an overview of the relation between endothelial dysfunction and cardiometabolic disease with an emphasis on novel mechanisms of endothelial dysfunction in T2DM that have been uncovered in FIHECs. We then discuss how FIHECs could be utilized in the assessment of the vascular benefits of current and future therapeutic treatments for patients with T2DM.
期刊介绍：
The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations, reviews and perspectives on the physiology of the heart, vasculature, and lymphatics. These articles include experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact and integrative animal and organ function to the cellular, subcellular, and molecular levels. The journal embraces new descriptions of these functions and their control systems, as well as their basis in biochemistry, biophysics, genetics, and cell biology. Preference is given to research that provides significant new mechanistic physiological insights that determine the performance of the normal and abnormal heart and circulation.
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