昆虫转录因子综合数据库与分析平台。

IF 5.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Hang Zhou, Jiejing Tang, Ziqi Cheng, Yang Mei
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引用次数: 0

摘要

转录因子是昆虫基因表达的关键调控因子,驱动着多种生物过程。尽管它们很重要,但一直缺乏一个专门的、全面的昆虫TFs数据库。为了解决这一问题,我们开发了昆虫数据库(http://www.insecttfdb.com/),这是一个包含21目、258科、1034属1796种昆虫的专业资源。从59,491,033个预测蛋白中,我们确定了1,570,627个tf,系统地分为六个结构组,并使用多种方法进行注释。大约87%的tf被成功地注释到已知的蛋白质上,增强了它们的功能可解释性。昆虫数据库提供了四个功能模块,包括物种检索、TF探索、序列比对和新序列预测分析工具。这些特点使其成为一个多功能的研究应用平台,从进化研究到功能基因组学和害虫管理。通过提供前所未有的分类覆盖范围和可靠的注释,昆虫ttfdb是促进我们对昆虫转录调控和基因调控网络理解的重要资源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
InsectTFDB: A Comprehensive Database and Analysis Platform for Insect Transcription Factors.

Transcription factors (TFs) are key regulators of gene expression, driving diverse biological processes in insects. Despite their importance, a dedicated and comprehensive database for insect TFs has been lacking. To address this gap, we developed InsectTFDB (http://www.insecttfdb.com/), a specialised resource encompassing 1796 insect species across 21 orders, 258 families and 1034 genera. From 59,491,033 predicted proteins, we identified 1,570,627 TFs, systematically classified into six structural groups and annotated using multiple approaches. Approximately 87% of these TFs were successfully annotated to known proteins, enhancing their functional interpretability. InsectTFDB offers a user-friendly interface with four functional modules, including tools for species retrieval, TF exploration, sequence alignment and predictive analysis of novel sequences. These features make it a versatile platform for diverse research applications, from evolutionary studies to functional genomics and pest management. By providing unprecedented taxonomic coverage and reliable annotations, InsectTFDB serves as a critical resource for advancing our understanding of transcriptional regulation and gene regulatory networks across the insects.

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来源期刊
Molecular Ecology Resources
Molecular Ecology Resources 生物-进化生物学
CiteScore
15.60
自引率
5.20%
发文量
170
审稿时长
3 months
期刊介绍: Molecular Ecology Resources promotes the creation of comprehensive resources for the scientific community, encompassing computer programs, statistical and molecular advancements, and a diverse array of molecular tools. Serving as a conduit for disseminating these resources, the journal targets a broad audience of researchers in the fields of evolution, ecology, and conservation. Articles in Molecular Ecology Resources are crafted to support investigations tackling significant questions within these disciplines. In addition to original resource articles, Molecular Ecology Resources features Reviews, Opinions, and Comments relevant to the field. The journal also periodically releases Special Issues focusing on resource development within specific areas.
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