关于免疫检查点抑制剂及其副作用，强化医师应该知道些什么？

IF 2.7 4区医学 Q2 CRITICAL CARE MEDICINE

Medicina Intensiva Pub Date : 2025-07-01 DOI:10.1016/j.medin.2024.502135

Viktor Yordanov Zlatkov Aleksandrov, Fernando Martínez Sagasti, Juncal Pérez-Somarriba Moreno, Helena Huertas Mondéjar

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引用次数: 0

摘要

在过去的十年中，免疫检查点抑制剂（ICI）的药理学组已经彻底改变了肿瘤学领域。由于这些治疗，某些癌症的生存率有所提高，但代价是某些免疫相关不良事件（irAE）导致的发病率和死亡率增加。本综述将集中在更频繁需要重症监护病房（ICU）入院的irAE。研究还探讨了ICI治疗患者的感染负担，不仅揭示了由控制不同irAE所需的免疫抑制引起的感染，还揭示了仅在ICI治疗患者中可见的独特免疫失调引起的特定感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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What should intensivists know about immune checkpoint inhibitors and their side effects?

The pharmacological group of immune checkpoint-inhibitors (ICI) has revolutionized the field of oncology in the last ten years. The improvements in the survival of certain cancers thanks to these treatments comes at the cost of an increased morbidity and mortality due to certain immune related adverse events (irAE). This review will concentrate on the irAE that more frequently require intensive care unit (ICU) admission. The infectious burden of patients treated with ICI is also explored, shining light not only on the infections caused by the immunosuppression needed to manage the different irAE, but also on the specific infections arising from a unique immune dysregulation only seen in ICI treated patients.

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来源期刊

Medicina Intensiva CRITICAL CARE MEDICINE-

CiteScore

2.70

自引率

20.00%

发文量

146

审稿时长

33 days

期刊介绍： Medicina Intensiva is the journal of the Spanish Society of Intensive Care Medicine and Coronary Units (SEMICYUC) and of Pan American and Iberian Federation of Societies of Intensive and Critical Care Medicine. Medicina Intensiva has become the reference publication in Spanish in its field. The journal mainly publishes Original Articles, Reviews, Clinical Notes, Consensus Documents, Images, and other information relevant to the specialty. All works go through a rigorous selection process. The journal accepts submissions of articles in English and in Spanish languages. The journal follows the publication requirements of the International Committee of Medical Journal Editors (ICMJE) and the Committee on Publication Ethics (COPE).