蛋白质中赖氨酸残基的修饰：维生素C的一种新的翻译后效应

IF 40.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Signal Transduction and Targeted Therapy Pub Date : 2025-06-30 DOI:10.1038/s41392-025-02288-7

Dieter Kabelitz

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引用次数: 0

摘要

在最近发表在《细胞》杂志上的一篇文章中，他和他的同事报告说，维生素C （VitC）改变蛋白质和肽中的赖氨酸残基，从而形成vityl -lysine，这一过程被他们称为vitcyation。他们发现信号传导和转录激活因子-1 （STAT1）的卵化增加了其磷酸化，从而促进癌细胞中干扰素通路的激活和抗肿瘤免疫

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Modification of lysine residues in proteins: a novel posttranslational effect of vitamin C

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Modification of lysine residues in proteins: a novel posttranslational effect of vitamin C

In a recent article published in Cell, He and colleagues reported that vitamin C (VitC) modifies lysine residues in proteins and peptides, thereby forming vitcyl-lysine, a process they have called vitcylation. They show that vitcylation of signal transducer and activator of transcription-1 (STAT1) increases its phosphorylation and thereby promotes interferon pathway activation in cancer cells and anti-tumor immunity.¹

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.