泌尿道卵黄囊体细胞肿瘤：一种罕见的分化形式。

IF 2.6 2区医学 Q2 PATHOLOGY

Human pathology Pub Date : 2025-07-01 DOI:10.1016/j.humpath.2025.105859

Nicholas Tedrow , Kenneth Ogan , Shreyas Joshi , Mehmet Asim Bilen , Jacqueline Brown , Bradley Carthon , Faisal Saeed , Jatin Gandhi , Elizabeth Genega , Lara Harik

{"title":"泌尿道卵黄囊体细胞肿瘤：一种罕见的分化形式。","authors":"Nicholas Tedrow , Kenneth Ogan , Shreyas Joshi , Mehmet Asim Bilen , Jacqueline Brown , Bradley Carthon , Faisal Saeed , Jatin Gandhi , Elizabeth Genega , Lara Harik","doi":"10.1016/j.humpath.2025.105859","DOIUrl":null,"url":null,"abstract":"<div><h3>Context</h3><div>Yolk sac tumor (YST) is a germ cell tumor, arising commonly from the gonads and rarely from other midline sites. Somatic Yolk sac tumors, arising from somatic malignancy, have been rarely reported in the gastrointestinal tract, gynecologic tract, and recently, in the urinary tract.</div></div><div><h3>Objective</h3><div>We share our institutional experience of somatic YST arising from the urothelium.</div></div><div><h3>Design</h3><div>Electronic medical records (EMR) were searched for cases of somatic YST differentiation in the urinary tract. Clinico-pathologic parameters were collected and reviewed, including clinical presentation, histologic and immunohistochemical findings, follow-up status, and duration.</div></div><div><h3>Results</h3><div>EMR search identified 4 cases of somatic yolk sac tumor arising from the urothelial tract. In 3 of 4 patients, the YST component was admixed with urothelial carcinoma. Histologic features of somatic YST included glandular differentiation with clearing of the cytoplasm. Papillary/pseudopapillary and solid components were also present. An immunohistochemical panel including AFP, Glypican 3 and SALL4 is helpful in confirming this rare form of divergent differentiation. Two cases presented de novo, one of them showed a pedunculated urethral mass composed of pure somatic YST; i12p on this case was negative.</div></div><div><h3>Conclusions</h3><div>Somatic YST differentiation in the urinary tract is a rare occurrence with potential for treatment implications. Familiarity with the histologic features is key to diagnosing this rare form of divergent differentiation. Molecular events leading to the development of somatic YST and optimal therapy remain unclear.</div></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"161 ","pages":"Article 105859"},"PeriodicalIF":2.6000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Somatic yolk sac tumors in the urinary tract: A form of rare divergent differentiation\",\"authors\":\"Nicholas Tedrow , Kenneth Ogan , Shreyas Joshi , Mehmet Asim Bilen , Jacqueline Brown , Bradley Carthon , Faisal Saeed , Jatin Gandhi , Elizabeth Genega , Lara Harik\",\"doi\":\"10.1016/j.humpath.2025.105859\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Context</h3><div>Yolk sac tumor (YST) is a germ cell tumor, arising commonly from the gonads and rarely from other midline sites. Somatic Yolk sac tumors, arising from somatic malignancy, have been rarely reported in the gastrointestinal tract, gynecologic tract, and recently, in the urinary tract.</div></div><div><h3>Objective</h3><div>We share our institutional experience of somatic YST arising from the urothelium.</div></div><div><h3>Design</h3><div>Electronic medical records (EMR) were searched for cases of somatic YST differentiation in the urinary tract. Clinico-pathologic parameters were collected and reviewed, including clinical presentation, histologic and immunohistochemical findings, follow-up status, and duration.</div></div><div><h3>Results</h3><div>EMR search identified 4 cases of somatic yolk sac tumor arising from the urothelial tract. In 3 of 4 patients, the YST component was admixed with urothelial carcinoma. Histologic features of somatic YST included glandular differentiation with clearing of the cytoplasm. Papillary/pseudopapillary and solid components were also present. An immunohistochemical panel including AFP, Glypican 3 and SALL4 is helpful in confirming this rare form of divergent differentiation. Two cases presented de novo, one of them showed a pedunculated urethral mass composed of pure somatic YST; i12p on this case was negative.</div></div><div><h3>Conclusions</h3><div>Somatic YST differentiation in the urinary tract is a rare occurrence with potential for treatment implications. Familiarity with the histologic features is key to diagnosing this rare form of divergent differentiation. Molecular events leading to the development of somatic YST and optimal therapy remain unclear.</div></div>\",\"PeriodicalId\":13062,\"journal\":{\"name\":\"Human pathology\",\"volume\":\"161 \",\"pages\":\"Article 105859\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Human pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0046817725001467\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human pathology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0046817725001467","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景：卵黄囊肿瘤（YST）是一种生殖细胞肿瘤，常见于性腺，很少发生在其他中线部位。体细胞性卵黄囊肿瘤是由体细胞性恶性肿瘤引起的，在胃肠道、妇科以及泌尿道中很少有报道。目的：分享尿路上皮引起的躯体性YST的机构经验。设计：检索电子病历（EMR），查找尿路体性YST转化病例。收集并回顾临床病理参数，包括临床表现、组织学和免疫组织化学结果、随访情况和持续时间。结果：EMR检索发现4例源自尿路上皮的卵黄囊瘤。4例患者中有3例伴有尿路上皮癌。体细胞性卵巢囊肿的组织学特征包括腺体分化和细胞质清除。假乳头状和实性成分也存在。包括AFP、Glypican 3和SALL4的免疫组化检查有助于确认这种罕见的转化。2例为新生，其中1例为带蒂尿道肿块，由纯粹的躯体性囊肿组成；这种情况下I12p是阴性的。结论：泌尿道体性囊肿转化是一种罕见的现象，具有潜在的治疗意义。熟悉组织学特征是诊断这种罕见的分化分化的关键。导致体细胞YST发展的分子事件和最佳治疗尚不清楚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Somatic yolk sac tumors in the urinary tract: A form of rare divergent differentiation

Context

Yolk sac tumor (YST) is a germ cell tumor, arising commonly from the gonads and rarely from other midline sites. Somatic Yolk sac tumors, arising from somatic malignancy, have been rarely reported in the gastrointestinal tract, gynecologic tract, and recently, in the urinary tract.

Objective

We share our institutional experience of somatic YST arising from the urothelium.

Design

Electronic medical records (EMR) were searched for cases of somatic YST differentiation in the urinary tract. Clinico-pathologic parameters were collected and reviewed, including clinical presentation, histologic and immunohistochemical findings, follow-up status, and duration.

Results

EMR search identified 4 cases of somatic yolk sac tumor arising from the urothelial tract. In 3 of 4 patients, the YST component was admixed with urothelial carcinoma. Histologic features of somatic YST included glandular differentiation with clearing of the cytoplasm. Papillary/pseudopapillary and solid components were also present. An immunohistochemical panel including AFP, Glypican 3 and SALL4 is helpful in confirming this rare form of divergent differentiation. Two cases presented de novo, one of them showed a pedunculated urethral mass composed of pure somatic YST; i12p on this case was negative.

Conclusions

Somatic YST differentiation in the urinary tract is a rare occurrence with potential for treatment implications. Familiarity with the histologic features is key to diagnosing this rare form of divergent differentiation. Molecular events leading to the development of somatic YST and optimal therapy remain unclear.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Human pathology 医学-病理学

CiteScore

5.30

自引率

6.10%

发文量

206

审稿时长

21 days

期刊介绍： Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.