{"title":"血浆醛固酮和肾素浓度对中国成年人血压变化和高血压风险的影响:一项基于人群的客家生物库研究。","authors":"Fuxiang Fang, Jingwei Lin, Mingli Li, Zheng Wen, Diman Mai, Jingwen Liu, Lingyu Ye, Yezhou Wu, Xuefang Liang, Fuhua Hu, Yibi Lan, Junwu Ran, Renzhi Tan, Yongchen Li, Libing Lai, Jinlian Li, Yongxian Wu, Zheng Lu, Shengzhu Huang, Chao Wang, Zengnan Mo","doi":"10.1016/j.eprac.2025.06.015","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The renin-angiotensin-aldosterone system (RAAS) has been implicated in regulating blood pressure (BP), yet its effects on BP-related phenotypes are not well characterized in the Chinese population.</p><p><strong>Methods: </strong>Based on 8914 participants from the Hakka Biobank (HKB) cohort of China, regression models, restricted cubic spline (RCS), and subgroup analyses were used to analyze associations of plasma aldosterone concentration (PAC), plasma renin concentration (PRC), and the aldosterone-to-renin ratio (ARR) with multiple BP-related phenotypes.</p><p><strong>Results: </strong>Multivariable regression models indicated that higher log-PAC and log-ARR, and lower log-PRC, were associated with higher systolic blood pressure, diastolic blood pressure, pulse pressure, and mean arterial pressure (all P < 0.001). A 1-unit higher log-PAC or lower log-PRC was linked to higher risks of systolic, diastolic, clinic, and systolic-diastolic hypertension, with the odds ratios (ORs) ranging from 1.67 (95% confidence interval [CI], 1.47-1.85) to 6.29 (95% CI, 4.48-8.83); and the OR of a higher log-ARR ranged from 1.66 (95% CI, 1.47-1.86) for systolic-diastolic hypertension to 2.42 (95% CI, 2.14-2.73) for clinic hypertension. Consistent associations were observed in subgroup and sensitivity analyses, as well as the participants with renin-independent aldosteronism compared to those with normal aldosterone concentration or renin-dependent aldosteronism (all P < 0.05). Moreover, RCS model revealed significant non-linear associations between log-PAC, log-PRC and log-ARR with hypertension (all P nonlinearity < 0.05).</p><p><strong>Conclusions: </strong>Higher PAC and ARR, lower PRC were associated with adverse BP variation and elevated risk of hypertension, especially among participants in the context of renin suppression or autonomous aldosterone secretion.</p>","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Plasma Aldosterone and Renin Concentrations with Blood Pressure Variation and Hypertension Risk in Chinese Adults: A Population-Based Hakka Biobank Study.\",\"authors\":\"Fuxiang Fang, Jingwei Lin, Mingli Li, Zheng Wen, Diman Mai, Jingwen Liu, Lingyu Ye, Yezhou Wu, Xuefang Liang, Fuhua Hu, Yibi Lan, Junwu Ran, Renzhi Tan, Yongchen Li, Libing Lai, Jinlian Li, Yongxian Wu, Zheng Lu, Shengzhu Huang, Chao Wang, Zengnan Mo\",\"doi\":\"10.1016/j.eprac.2025.06.015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>The renin-angiotensin-aldosterone system (RAAS) has been implicated in regulating blood pressure (BP), yet its effects on BP-related phenotypes are not well characterized in the Chinese population.</p><p><strong>Methods: </strong>Based on 8914 participants from the Hakka Biobank (HKB) cohort of China, regression models, restricted cubic spline (RCS), and subgroup analyses were used to analyze associations of plasma aldosterone concentration (PAC), plasma renin concentration (PRC), and the aldosterone-to-renin ratio (ARR) with multiple BP-related phenotypes.</p><p><strong>Results: </strong>Multivariable regression models indicated that higher log-PAC and log-ARR, and lower log-PRC, were associated with higher systolic blood pressure, diastolic blood pressure, pulse pressure, and mean arterial pressure (all P < 0.001). A 1-unit higher log-PAC or lower log-PRC was linked to higher risks of systolic, diastolic, clinic, and systolic-diastolic hypertension, with the odds ratios (ORs) ranging from 1.67 (95% confidence interval [CI], 1.47-1.85) to 6.29 (95% CI, 4.48-8.83); and the OR of a higher log-ARR ranged from 1.66 (95% CI, 1.47-1.86) for systolic-diastolic hypertension to 2.42 (95% CI, 2.14-2.73) for clinic hypertension. Consistent associations were observed in subgroup and sensitivity analyses, as well as the participants with renin-independent aldosteronism compared to those with normal aldosterone concentration or renin-dependent aldosteronism (all P < 0.05). Moreover, RCS model revealed significant non-linear associations between log-PAC, log-PRC and log-ARR with hypertension (all P nonlinearity < 0.05).</p><p><strong>Conclusions: </strong>Higher PAC and ARR, lower PRC were associated with adverse BP variation and elevated risk of hypertension, especially among participants in the context of renin suppression or autonomous aldosterone secretion.</p>\",\"PeriodicalId\":11682,\"journal\":{\"name\":\"Endocrine Practice\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.eprac.2025.06.015\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.eprac.2025.06.015","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Effects of Plasma Aldosterone and Renin Concentrations with Blood Pressure Variation and Hypertension Risk in Chinese Adults: A Population-Based Hakka Biobank Study.
Objectives: The renin-angiotensin-aldosterone system (RAAS) has been implicated in regulating blood pressure (BP), yet its effects on BP-related phenotypes are not well characterized in the Chinese population.
Methods: Based on 8914 participants from the Hakka Biobank (HKB) cohort of China, regression models, restricted cubic spline (RCS), and subgroup analyses were used to analyze associations of plasma aldosterone concentration (PAC), plasma renin concentration (PRC), and the aldosterone-to-renin ratio (ARR) with multiple BP-related phenotypes.
Results: Multivariable regression models indicated that higher log-PAC and log-ARR, and lower log-PRC, were associated with higher systolic blood pressure, diastolic blood pressure, pulse pressure, and mean arterial pressure (all P < 0.001). A 1-unit higher log-PAC or lower log-PRC was linked to higher risks of systolic, diastolic, clinic, and systolic-diastolic hypertension, with the odds ratios (ORs) ranging from 1.67 (95% confidence interval [CI], 1.47-1.85) to 6.29 (95% CI, 4.48-8.83); and the OR of a higher log-ARR ranged from 1.66 (95% CI, 1.47-1.86) for systolic-diastolic hypertension to 2.42 (95% CI, 2.14-2.73) for clinic hypertension. Consistent associations were observed in subgroup and sensitivity analyses, as well as the participants with renin-independent aldosteronism compared to those with normal aldosterone concentration or renin-dependent aldosteronism (all P < 0.05). Moreover, RCS model revealed significant non-linear associations between log-PAC, log-PRC and log-ARR with hypertension (all P nonlinearity < 0.05).
Conclusions: Higher PAC and ARR, lower PRC were associated with adverse BP variation and elevated risk of hypertension, especially among participants in the context of renin suppression or autonomous aldosterone secretion.
期刊介绍:
Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.