tRNA的表达和修饰是血食性节肢动物生物学的关键组成部分。

IF 4.8 1区农林科学 Q1 BIOLOGY

Current opinion in insect science Pub Date : 2025-06-25 DOI:10.1016/j.cois.2025.101404

Melissa Kelley , Patrick A Limbach , Joshua B Benoit

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引用次数: 0

摘要

蛋白质组的改变是血食性节肢动物生理过程所必需的。为了解释这一点，转移RNA （tRNA）水平和化学修饰被用于蛋白质合成。在这里，我们讨论了tRNA在供血系统中的调控概述。这个主题扩展到宿主-微生物的相互作用，因为修改需要从共生体和饮食中获得微量营养素。最后，修饰可能涉及媒介和病原体之间的分子动力学，这可能影响到脊椎动物宿主的传播。tRNA水平及其修饰可能在蚊子-微生物组-病原体之间的三方相互作用中发挥关键作用，为抑制病原体传播提供了新的靶点。

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tRNA expression and modifications as critical components in the biology of blood-feeding arthropods

Alterations to the proteome are necessary for physiological processes in blood-feeding arthropods. To account for this, transfer RNA (tRNA) levels and chemical modifications are utilized for protein synthesis. Here, we discuss an overview of tRNA regulation in blood-feeding systems. This topic expands to host–microbial interactions as tRNA modifications require micronutrients acquired from symbionts and diet. Lastly, modifications are likely involved in the molecular dynamics between vectors and pathogens, which may impact transmission to vertebrate hosts. The tRNA levels and their modifications likely play crucial roles in the tripartite interaction between mosquitoes, their microbiome, and transmissable pathogens, providing a novel target to suppress the spread of mosquito-borne diseases.

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来源期刊

Current opinion in insect science BIOLOGYECOLOGYENTOMOLOGY-ECOLOGY

CiteScore

10.40

自引率

1.90%

发文量

113

期刊介绍： Current Opinion in Insect Science is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up–to–date with the expanding volume of information published in the field of Insect Science. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following 11 areas are covered by Current Opinion in Insect Science. -Ecology -Insect genomics -Global Change Biology -Molecular Physiology (Including Immunity) -Pests and Resistance -Parasites, Parasitoids and Biological Control -Behavioural Ecology -Development and Regulation -Social Insects -Neuroscience -Vectors and Medical and Veterinary Entomology There is also a section that changes every year to reflect hot topics in the field. Section Editors, who are major authorities in their area, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors commission articles from leading scientists on each topic that they have selected and the commissioned authors write short review articles in which they present recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.