雄性激素和雌性激素在化脓性汗腺炎中的作用——系统综述。

Peter Theut Riis, Hans Christian Ring, Lotte Themstrup, Gregor Borut Jemec
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引用次数: 0

摘要

化脓性汗腺炎是一种炎症性皮肤病。一些观察结果暗示性激素可能在其发病机制中起作用。HS在女性中更常见,疾病的严重程度似乎根据月经周期而有所不同。此外,HS和寻常痤疮之间也有相似之处,表明性激素可能在这种情况下起作用。因此,在许多观察性研究和一些介入性研究中,已经探讨了雄激素和雌激素在HS中的作用;然而,这些研究经常报告相互矛盾的结果。本系统综述包括59篇独特的文章,旨在对现有研究进行概述。包含自然变化信息的文章,月经和怀孕期间的严重变化,以及HS患者血清激素水平和激素操纵疗法的治疗选择的文章都被纳入并呈现在本系统综述中。我们的研究结果显示,HS患者的性激素水平似乎没有增加,他们的激素水平处于正常范围内。虽然孕酮和雌激素水平的下降似乎与绝经前妇女的疾病发作相吻合,但这种联系是推测性的,需要实验证实。抗雄激素治疗可能是治疗HS的一种有价值的方法,但缺乏随机对照试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Androgens and Estrogens in Hidradenitis Suppurativa - A Systematic Review.

Hidradenitis suppurativa (HS) is an inflammatory skin disease. Several observations imply that sex hormones may play a role in its pathogenesis. HS is more common in women, and the disease severity appears to vary in intensity according to the menstrual cycle. In addition, parallels have been drawn between HS and acne vulgaris, suggesting that sex hormones may play a role in the condition. The role of androgens and estrogens in HS has therefore been explored in numerous observational and some interventional studies; however, the studies have often reported conflicting results. This systematic review includes 59 unique articles and aims to give an overview of the available research. Articles containing information on natural variation, severity changes during menstruation and pregnancy, as well as articles on serum levels of hormones in patients with HS and the therapeutic options of hormonal manipulation therapy have all been included and are presented in this systematic review. Our results show that patients with HS do not seem to have increased levels of sex hormones and that their hormone levels lie within the normal range. While decreasing levels of progesterone and estrogen seem to coincide with disease flares in premenopausal women, the association is speculative and requires experimental confirmation. Antiandrogen treatment could be a valuable approach in treating HS, however randomized control trials are lacking.

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