[在多耐药大肠杆菌实验中美西利南和二氧化二胺的化疗效果]。

Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-09-01

A V Antipov

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引用次数: 0

摘要

在大肠杆菌675多耐药变异引起的白化小鼠大肠杆菌败血症模型上研究了美西利南和二氧化二嗪的化疗疗效。结果表明，与不含质粒的对照相比，RI质粒的存在显著降低了美西林的化疗疗效，而R64质粒的存在没有改变药物疗效。结果表明，RI和R222质粒在病原菌细胞中的存在提高了二氧化素的药效，而pKM-101质粒则相反。观察大肠杆菌675体外对二氧化二胺的耐药水平与动物化疗疗效的相关性。

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[Chemotherapeutic effectiveness of mecillinam and dioxidine in an experiment using polyresistant Escherichia coli].

Chemotherapeutic efficacy of mecillinam and dioxidine was studied on a model of Escherichia coli septicemia of albino mice caused by polyresistant variants of E. coli 675. It was shown that the presence of RI plasmid in the bacterial cells markedly lowered the mecillinam chemotherapeutic efficacy whereas the presence of R64 plasmid did not change the drug efficacy as compared to the plasmid-free controls. It was noted that the presence of RI and R222 plasmids in the pathogen cells increased the dioxidine efficacy while pKM-101 plasmid had a contrary effect. Correlation between the level of dioxidine resistance of E. coli 675 in vitro and the drug chemotherapeutic efficacy in animals was observed.

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Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology

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