多发性硬化症：病理学家的实用回顾。

IF 3 Q3 PATHOLOGY

Journal of Pathology and Translational Medicine Pub Date : 2025-07-01 Epub Date: 2025-06-27 DOI:10.4132/jptm.2025.05.20

Rachel A Multz, Pouya Jamshidi, Jared T Ahrendsen

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引用次数: 0

摘要

多发性硬化症（MS）是一种免疫介导的中枢神经系统脱髓鞘疾病。它是一种慢性疾病，导致神经功能障碍，在时间上（多次离散发作）和空间上（涉及多个部位）弥散。组织学上，多发性硬化症的特征是髓磷脂的局部丢失和轴突的相对保存。本文将讨论多发性硬化症的流行病学、临床、实验室、放射学和病理特征，并简要介绍该病的鉴别诊断、治疗和预后，特别是与组织标本的病理解释有关。

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Multiple sclerosis: a practical review for pathologists.

Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of the central nervous system. It is a chronic disorder resulting in neurologic dysfunction that is disseminated both in time (multiple discrete episodes) and space (involving multiple sites). Histologically, MS is characterized by localized loss of myelin with relative preservation of axons. This review will discuss the epidemiology, clinical, laboratory, radiologic, and pathologic features of multiple sclerosis, as well as briefly touch on the differential diagnosis, treatment, and prognosis of the disease, especially as they relate to the pathologic interpretation of tissue specimens.

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来源期刊

Journal of Pathology and Translational Medicine PATHOLOGY-

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

14 weeks

期刊介绍： The Journal of Pathology and Translational Medicine is an open venue for the rapid publication of major achievements in various fields of pathology, cytopathology, and biomedical and translational research. The Journal aims to share new insights into the molecular and cellular mechanisms of human diseases and to report major advances in both experimental and clinical medicine, with a particular emphasis on translational research. The investigations of human cells and tissues using high-dimensional biology techniques such as genomics and proteomics will be given a high priority. Articles on stem cell biology are also welcome. The categories of manuscript include original articles, review and perspective articles, case studies, brief case reports, and letters to the editor.