介入手术后冠状动脉支架的血流动力学和接触模拟研究。

IF 2.7 4区 医学 Q3 BIOPHYSICS
Miaoxian Xu, Ning Dang, Hui Tang, Hao Wei, Shikun Zhang, Yinghong Zhao
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引用次数: 0

摘要

目标。介入治疗是中重度冠状动脉粥样硬化的主要治疗方式。然而,支架植入后的潜在并发症会给患者带来重大风险。方法:通过建立三种不同类型的冠状动脉支架模型,利用临床血流储备分数数据,采用流固耦合分析方法模拟支架植入术后的血流动力学改变和血管壁反应。主要的结果。研究表明,支架植入可引起支架附近复杂的血流动力学改变,特别是在支架与血管壁接触的结合处。虽然三种支架类型的血流动力学特征表现出总体一致性,但局部血流动力学的差异源于每种支架设计固有的不同孔隙密度。值得注意的是,相对于其他类型的支架,b型支架具有中等孔隙密度的特点,具有相对稳定的血流动力学。此外,支架植入会影响到支架未覆盖的血管壁区域,这些区域的血流动力学也会发生显著变化。意义:支架植入对血管内血流动力学有显著影响。具体来说,支架附近异常的血流动力学改变会对血管壁造成损伤,从而加速并发症的发生。此外,不同支架引起的血流动力学变化差异很大,并且已经观察到中等网格间距的支架在缓解不良血流动力学影响方面表现出更好的性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hemodynamics and contact simulation investigation of coronary artery stents after interventional surgery.

Objective.Interventional therapy represents a primary treatment modality for moderate to severe coronary atherosclerosis. However, potential complications following stent implantation can pose significant risks to patients. This study aims to explore the relationship between aberrant hemodynamic patterns and the incidence of post-stent implantation complications.Approach.By creating models of three distinct types of coronary artery stents and utilizing clinical fractional flow reserve data, this research employs fluid-structure interaction analyses to simulate the hemodynamic alterations and vascular wall responses post-stent implantation.Main results.It is indicated that implantation of stents can induce complex hemodynamic modifications in the vicinity of the stent, particularly at the juncture where the stent contacts the vascular wall. While the hemodynamic profiles of the three stent types exhibit general consistency, distinctions in local hemodynamics arise from the varied pore densities inherent to each stent design. Notably, the B-type stent, characterized by their moderate pore density, demonstrates comparatively stable hemodynamics relative to the other stent types. Additionally, stent implantation impacts areas of the vascular wall not covered by the stent, with notable hemodynamic changes also manifesting in these regions.Significance.The implantation of stents has a significant impact on the hemodynamics inside the blood vessels. Specifically, abnormal hemodynamic changes near the stents can inflict damage to the blood vessel wall, thus accelerating the occurrence of complications. Moreover, the hemodynamic changes elicited by different stents vary significantly, and it has been observed that stents with moderate grid spacing exhibit superior performance in mitigating adverse hemodynamic effects.

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来源期刊
Physiological measurement
Physiological measurement 生物-工程:生物医学
CiteScore
5.50
自引率
9.40%
发文量
124
审稿时长
3 months
期刊介绍: Physiological Measurement publishes papers about the quantitative assessment and visualization of physiological function in clinical research and practice, with an emphasis on the development of new methods of measurement and their validation. Papers are published on topics including: applied physiology in illness and health electrical bioimpedance, optical and acoustic measurement techniques advanced methods of time series and other data analysis biomedical and clinical engineering in-patient and ambulatory monitoring point-of-care technologies novel clinical measurements of cardiovascular, neurological, and musculoskeletal systems. measurements in molecular, cellular and organ physiology and electrophysiology physiological modeling and simulation novel biomedical sensors, instruments, devices and systems measurement standards and guidelines.
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