{"title":"介入手术后冠状动脉支架的血流动力学和接触模拟研究。","authors":"Miaoxian Xu, Ning Dang, Hui Tang, Hao Wei, Shikun Zhang, Yinghong Zhao","doi":"10.1088/1361-6579/ade652","DOIUrl":null,"url":null,"abstract":"<p><p><i>Objective.</i>Interventional therapy represents a primary treatment modality for moderate to severe coronary atherosclerosis. However, potential complications following stent implantation can pose significant risks to patients. This study aims to explore the relationship between aberrant hemodynamic patterns and the incidence of post-stent implantation complications.<i>Approach.</i>By creating models of three distinct types of coronary artery stents and utilizing clinical fractional flow reserve data, this research employs fluid-structure interaction analyses to simulate the hemodynamic alterations and vascular wall responses post-stent implantation.<i>Main results.</i>It is indicated that implantation of stents can induce complex hemodynamic modifications in the vicinity of the stent, particularly at the juncture where the stent contacts the vascular wall. While the hemodynamic profiles of the three stent types exhibit general consistency, distinctions in local hemodynamics arise from the varied pore densities inherent to each stent design. Notably, the B-type stent, characterized by their moderate pore density, demonstrates comparatively stable hemodynamics relative to the other stent types. Additionally, stent implantation impacts areas of the vascular wall not covered by the stent, with notable hemodynamic changes also manifesting in these regions.<i>Significance.</i>The implantation of stents has a significant impact on the hemodynamics inside the blood vessels. Specifically, abnormal hemodynamic changes near the stents can inflict damage to the blood vessel wall, thus accelerating the occurrence of complications. Moreover, the hemodynamic changes elicited by different stents vary significantly, and it has been observed that stents with moderate grid spacing exhibit superior performance in mitigating adverse hemodynamic effects.</p>","PeriodicalId":20047,"journal":{"name":"Physiological measurement","volume":"46 6","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hemodynamics and contact simulation investigation of coronary artery stents after interventional surgery.\",\"authors\":\"Miaoxian Xu, Ning Dang, Hui Tang, Hao Wei, Shikun Zhang, Yinghong Zhao\",\"doi\":\"10.1088/1361-6579/ade652\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Objective.</i>Interventional therapy represents a primary treatment modality for moderate to severe coronary atherosclerosis. However, potential complications following stent implantation can pose significant risks to patients. This study aims to explore the relationship between aberrant hemodynamic patterns and the incidence of post-stent implantation complications.<i>Approach.</i>By creating models of three distinct types of coronary artery stents and utilizing clinical fractional flow reserve data, this research employs fluid-structure interaction analyses to simulate the hemodynamic alterations and vascular wall responses post-stent implantation.<i>Main results.</i>It is indicated that implantation of stents can induce complex hemodynamic modifications in the vicinity of the stent, particularly at the juncture where the stent contacts the vascular wall. While the hemodynamic profiles of the three stent types exhibit general consistency, distinctions in local hemodynamics arise from the varied pore densities inherent to each stent design. Notably, the B-type stent, characterized by their moderate pore density, demonstrates comparatively stable hemodynamics relative to the other stent types. Additionally, stent implantation impacts areas of the vascular wall not covered by the stent, with notable hemodynamic changes also manifesting in these regions.<i>Significance.</i>The implantation of stents has a significant impact on the hemodynamics inside the blood vessels. Specifically, abnormal hemodynamic changes near the stents can inflict damage to the blood vessel wall, thus accelerating the occurrence of complications. Moreover, the hemodynamic changes elicited by different stents vary significantly, and it has been observed that stents with moderate grid spacing exhibit superior performance in mitigating adverse hemodynamic effects.</p>\",\"PeriodicalId\":20047,\"journal\":{\"name\":\"Physiological measurement\",\"volume\":\"46 6\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physiological measurement\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1088/1361-6579/ade652\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physiological measurement","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1361-6579/ade652","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOPHYSICS","Score":null,"Total":0}
Hemodynamics and contact simulation investigation of coronary artery stents after interventional surgery.
Objective.Interventional therapy represents a primary treatment modality for moderate to severe coronary atherosclerosis. However, potential complications following stent implantation can pose significant risks to patients. This study aims to explore the relationship between aberrant hemodynamic patterns and the incidence of post-stent implantation complications.Approach.By creating models of three distinct types of coronary artery stents and utilizing clinical fractional flow reserve data, this research employs fluid-structure interaction analyses to simulate the hemodynamic alterations and vascular wall responses post-stent implantation.Main results.It is indicated that implantation of stents can induce complex hemodynamic modifications in the vicinity of the stent, particularly at the juncture where the stent contacts the vascular wall. While the hemodynamic profiles of the three stent types exhibit general consistency, distinctions in local hemodynamics arise from the varied pore densities inherent to each stent design. Notably, the B-type stent, characterized by their moderate pore density, demonstrates comparatively stable hemodynamics relative to the other stent types. Additionally, stent implantation impacts areas of the vascular wall not covered by the stent, with notable hemodynamic changes also manifesting in these regions.Significance.The implantation of stents has a significant impact on the hemodynamics inside the blood vessels. Specifically, abnormal hemodynamic changes near the stents can inflict damage to the blood vessel wall, thus accelerating the occurrence of complications. Moreover, the hemodynamic changes elicited by different stents vary significantly, and it has been observed that stents with moderate grid spacing exhibit superior performance in mitigating adverse hemodynamic effects.
期刊介绍:
Physiological Measurement publishes papers about the quantitative assessment and visualization of physiological function in clinical research and practice, with an emphasis on the development of new methods of measurement and their validation.
Papers are published on topics including:
applied physiology in illness and health
electrical bioimpedance, optical and acoustic measurement techniques
advanced methods of time series and other data analysis
biomedical and clinical engineering
in-patient and ambulatory monitoring
point-of-care technologies
novel clinical measurements of cardiovascular, neurological, and musculoskeletal systems.
measurements in molecular, cellular and organ physiology and electrophysiology
physiological modeling and simulation
novel biomedical sensors, instruments, devices and systems
measurement standards and guidelines.