性少数群体压力、适应负荷、药物和酒精使用之间的关系:酷儿健康研究方案-纵向可行性评估

IF 1.5 Q3 HEALTH CARE SCIENCES & SERVICES
Nathan Grant Smith, Tzuan A Chen, Robert-Paul Juster, Ezemenari M Obasi, Jacob S Crocker
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引用次数: 0

摘要

背景:性少数群体的药物使用率不成比例地高于异性恋群体。少数群体压力理论认为,对性少数群体中不成比例的物质使用的一种解释是,持有少数群体身份所带来的社会压力增加。这种少数族裔压力与无数负面的心理健康结果有关,包括酗酒和吸毒。此外,新兴的研究已经开始证明少数民族压力和压力生理失调之间的联系。虽然动物和人类模型已经证明了应激生理失调与物质使用结果之间的联系,但迄今为止,还没有研究检验了应激生理在预测性少数群体的物质使用方面在少数群体应激框架中所起的作用。酷儿健康研究旨在探索少数族裔压力、压力生理学(特别是适应负荷,慢性压力对身体和大脑造成的累积“磨损”)和物质使用之间的纵向联系。目的:本研究旨在评估收集纵向数据的可行性,以探索少数民族应力过程、适应负荷、药物和酒精使用之间的时间联系,并获得效应大小的估计,以确定进行全面纵向研究所需的适当样本量。方法:本可行性研究采用三波纵向设计,包括自我报告调查、研究者辅助的时间轴回访以评估药物和酒精使用情况,以及收集血液和人体测量数据以测量每个时间点的适应负荷。共有40名不同民族和种族的性少数成人参与者(年龄在18-60岁)将被招募。结果:该研究于2023年7月31日获得休斯顿大学机构审查委员会批准(STUDY00004277)。招聘于2024年6月开始。截至2025年2月,46名参与者的初始样本完成了第一次访问,第二次访问正在进行中。我们预计所有的学习活动将在2025年7月完成。结论:研究结果可为制定有针对性的预防和治疗干预措施提供参考。此外,这项研究将为探索影响这一高危人群成瘾的各种风险和弹性因素提供一个创新的框架。最终,研究结果对公共卫生具有重要影响,并有可能减少药物使用和成瘾造成的许多可怕的经济和健康后果。国际注册报告标识符(irrid): DERR1-10.2196/73070。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations Among Minority Stress, Allostatic Load, and Drug and Alcohol Use in Sexual Minorities: Protocol for the Queer Health Study-a Longitudinal Feasibility Evaluation.

Background: Substance use rates among sexual minorities are disproportionately greater than that of their heterosexual counterparts. Minority stress theory posits that one explanation for disproportionate substance use in sexual minority populations is a result of increased social stress associated with holding a minoritized identity. This minority stress has been linked to a myriad of negative mental health outcomes, including alcohol and drug use. In addition, emerging research has begun to demonstrate links between minority stress and stress physiology dysregulation. While animal and human models have demonstrated links between stress physiology dysregulation and substance use outcomes, to date, no studies have examined the role that stress physiology plays within a minority stress framework in predicting substance use among sexual minorities. The Queer Health Study was designed to explore the longitudinal links among minority stress, stress physiology (specifically, allostatic load, the cumulative "wear and tear" on the body and brain as a result of chronic stress), and substance use.

Objective: This study aims to assess the feasibility of collecting longitudinal data to explore the temporal links between minority stress processes, allostatic load, and drug and alcohol use, as well as to obtain estimates of effect size to determine the appropriate sample size necessary to conduct a fully powered longitudinal study.

Methods: This feasibility study is a 3-wave longitudinal design consisting of a self-report survey, researcher-assisted Timeline Followback to assess for drug and alcohol use, and blood and anthropometric data collection to measure allostatic load at each of the time points. A total of 40 ethnically and racially diverse sexual minority adult participants (aged 18-60 years) will be enrolled.

Results: The study received University of Houston institutional review board approval on July 31, 2023 (STUDY00004277). Recruitment began in June 2024. As of February 2025, the initial sample of 46 participants completed the time 1 visit, and time 2 visits are ongoing. We estimate that all study activities will be completed by July 2025.

Conclusions: Results can inform the development of targeted prevention and treatment interventions. In addition, this research will provide an innovative framework for exploring diverse risk and resilience factors impacting addiction in this at-risk population. Ultimately, results have important implications for public health and have the potential to reduce the many dire economic and health consequences of drug use and addiction.

International registered report identifier (irrid): DERR1-10.2196/73070.

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