Taha Koray Sahin, Deniz Can Guven, Yakup Ozbay, Firat Atak, Sevtap Arslan, Mehmet Cihan İcli, Latif Karahan, Yunus Kaygusuz, Zafer Arik, Omer Dizdar, Mustafa Erman, Suayib Yalcin, Mehmet Ruhi Onur, Sercan Aksoy
{"title":"白蛋白-肌骨化症作为免疫检查点抑制剂治疗患者的预后生物标志物。","authors":"Taha Koray Sahin, Deniz Can Guven, Yakup Ozbay, Firat Atak, Sevtap Arslan, Mehmet Cihan İcli, Latif Karahan, Yunus Kaygusuz, Zafer Arik, Omer Dizdar, Mustafa Erman, Suayib Yalcin, Mehmet Ruhi Onur, Sercan Aksoy","doi":"10.1080/1750743X.2025.2525743","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Although immune checkpoint inhibitors (ICIs) have heralded a new era in cancer treatment, many patients do not respond, underscoring the need for biomarkers. The albumin-myosteatosis gauge (AMG) is a recently developed integrated measure of myosteatosis and serum albumin levels, reflecting systemic inflammation and malnutrition. Herein, we investigate the prognostic value of AMG in patients with advanced cancer treated with ICIs.</p><p><strong>Methods: </strong>A total of 308 patients with advanced cancer treated with ICIs were included. Skeletal muscle index and skeletal muscle radiodensity (SMD) were measured from computed tomography images obtained at the level of the L3 vertebra. The AMG was calculated by multiplying SMD by albumin and expressed as an arbitrary unit.</p><p><strong>Results: </strong>The median age (interquartile range) was 63 (55-70), and 198 (64.3%) were male. Non-small cell lung cancer (NSCLC) was the most common primary cancer (28.2%), followed by RCC (20.8%) and melanoma (20.2%). Multivariable analyses revealed that lower AMG values were independently associated with decreased OS (HR:1.37; 95%CI:1.03-1.82; <i>p</i> = 0.032) and PFS (HR:1.39; 95% CI:1.07-1.79;<i>p</i> = 0.012) compared to the AMG high-group.</p><p><strong>Conclusion: </strong>Our findings suggest AMG, an easily accessible novel biomarker, is an independent prognostic factor for survival in patients with advanced cancer treated with ICIs.</p>","PeriodicalId":13328,"journal":{"name":"Immunotherapy","volume":" ","pages":"657-665"},"PeriodicalIF":2.7000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269662/pdf/","citationCount":"0","resultStr":"{\"title\":\"Albumin-myosteatosis gauge as a prognostic biomarker in patients treated with immune checkpoint inhibitors.\",\"authors\":\"Taha Koray Sahin, Deniz Can Guven, Yakup Ozbay, Firat Atak, Sevtap Arslan, Mehmet Cihan İcli, Latif Karahan, Yunus Kaygusuz, Zafer Arik, Omer Dizdar, Mustafa Erman, Suayib Yalcin, Mehmet Ruhi Onur, Sercan Aksoy\",\"doi\":\"10.1080/1750743X.2025.2525743\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Although immune checkpoint inhibitors (ICIs) have heralded a new era in cancer treatment, many patients do not respond, underscoring the need for biomarkers. The albumin-myosteatosis gauge (AMG) is a recently developed integrated measure of myosteatosis and serum albumin levels, reflecting systemic inflammation and malnutrition. Herein, we investigate the prognostic value of AMG in patients with advanced cancer treated with ICIs.</p><p><strong>Methods: </strong>A total of 308 patients with advanced cancer treated with ICIs were included. Skeletal muscle index and skeletal muscle radiodensity (SMD) were measured from computed tomography images obtained at the level of the L3 vertebra. The AMG was calculated by multiplying SMD by albumin and expressed as an arbitrary unit.</p><p><strong>Results: </strong>The median age (interquartile range) was 63 (55-70), and 198 (64.3%) were male. Non-small cell lung cancer (NSCLC) was the most common primary cancer (28.2%), followed by RCC (20.8%) and melanoma (20.2%). Multivariable analyses revealed that lower AMG values were independently associated with decreased OS (HR:1.37; 95%CI:1.03-1.82; <i>p</i> = 0.032) and PFS (HR:1.39; 95% CI:1.07-1.79;<i>p</i> = 0.012) compared to the AMG high-group.</p><p><strong>Conclusion: </strong>Our findings suggest AMG, an easily accessible novel biomarker, is an independent prognostic factor for survival in patients with advanced cancer treated with ICIs.</p>\",\"PeriodicalId\":13328,\"journal\":{\"name\":\"Immunotherapy\",\"volume\":\" \",\"pages\":\"657-665\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269662/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunotherapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/1750743X.2025.2525743\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunotherapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/1750743X.2025.2525743","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/27 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Albumin-myosteatosis gauge as a prognostic biomarker in patients treated with immune checkpoint inhibitors.
Background: Although immune checkpoint inhibitors (ICIs) have heralded a new era in cancer treatment, many patients do not respond, underscoring the need for biomarkers. The albumin-myosteatosis gauge (AMG) is a recently developed integrated measure of myosteatosis and serum albumin levels, reflecting systemic inflammation and malnutrition. Herein, we investigate the prognostic value of AMG in patients with advanced cancer treated with ICIs.
Methods: A total of 308 patients with advanced cancer treated with ICIs were included. Skeletal muscle index and skeletal muscle radiodensity (SMD) were measured from computed tomography images obtained at the level of the L3 vertebra. The AMG was calculated by multiplying SMD by albumin and expressed as an arbitrary unit.
Results: The median age (interquartile range) was 63 (55-70), and 198 (64.3%) were male. Non-small cell lung cancer (NSCLC) was the most common primary cancer (28.2%), followed by RCC (20.8%) and melanoma (20.2%). Multivariable analyses revealed that lower AMG values were independently associated with decreased OS (HR:1.37; 95%CI:1.03-1.82; p = 0.032) and PFS (HR:1.39; 95% CI:1.07-1.79;p = 0.012) compared to the AMG high-group.
Conclusion: Our findings suggest AMG, an easily accessible novel biomarker, is an independent prognostic factor for survival in patients with advanced cancer treated with ICIs.
期刊介绍：
Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field.
Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.
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