小剂量Venetoclax联合伏立康唑治疗急性髓系白血病不适合强化化疗的安全性和有效性

IF 3.3 4区 医学 Q2 HEMATOLOGY
Xinyao Liu, Danchen Meng, Yuxin Li, Min Ruan, Zhenqi Huang, Wei Wu, Jian Ge, Jichun Yang, Zhangbiao Long
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引用次数: 0

摘要

低剂量venetoclax联合强效CYP3A4抑制剂voriconazole用于不适合强化化疗的急性髓系白血病(AML)患者。然而,该方案的有效性和安全性尚未得到很好的研究。我们分析了54例患者的临床资料,中位年龄为67岁。30例患者接受标准剂量venetoclax +阿扎胞苷(队列1),而另外24例患者接受低剂量venetoclax +伏立康唑+阿扎胞苷(队列2)。复合完全缓解(完全缓解或完全缓解伴血液学不完全恢复;队列1的CR/CRi为76.7%(23/30),队列2为87.5% (21/24)(p = 0.483)。在中位随访16个月时,队列1的中位无进展生存期为12个月,队列2的中位无进展生存期为18个月(p = 0.241)。队列1中位总生存期为14个月,队列2中位总生存期为19个月(p = 0.453)。主要不良事件包括细胞减少和感染。在队列1和队列2中,分别有36.7%和20.8%的患者出现了3级或更高的感染。总之,本研究证明了低剂量venetoclax联合voriconazole治疗不适合AML的安全性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Safety and Efficacy of Low-Dose Venetoclax Plus Voriconazole in Patients With Acute Myeloid Leukemia Unfit for Intensive Chemotherapy

Low-dose venetoclax plus strong CYP3A4 inhibitor voriconazole were commonly used for acute myeloid leukemia (AML) patients who were unfit for intensive chemotherapy in China. However, the efficacy and safety of this schedule have not been well investigated. We analyzed clinical data from 54 patients with a median age of 67 years. Thirty patients received a standard dose of venetoclax plus azacitidine (cohort 1), whereas another 24 patients received low-dose venetoclax plus voriconazole plus azacitidine (cohort 2). The composite complete remission (complete remission or complete remission with incomplete hematologic recovery; CR/CRi) rate was 76.7% (23/30) in cohort 1 and 87.5% (21/24) in cohort 2 (p = 0.483). At a median follow-up of 16 months, the median progression-free survival was 12 months in cohort 1 and 18 months in cohort 2 (p = 0.241). The median overall survival was 14 months in cohort 1 and 19 months in cohort 2 (p = 0.453). Key adverse events included cytopenia and infections. Grade 3 or higher infections occurred in 36.7% of the patients in cohort 1 and 20.8% of those in cohort 2. In conclusion, this study demonstrated the safety and effectiveness of the combination of low-dose venetoclax and voriconazole in unfit AML.

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来源期刊
Hematological Oncology
Hematological Oncology 医学-血液学
CiteScore
4.20
自引率
6.10%
发文量
147
审稿时长
>12 weeks
期刊介绍: Hematological Oncology considers for publication articles dealing with experimental and clinical aspects of neoplastic diseases of the hemopoietic and lymphoid systems and relevant related matters. Translational studies applying basic science to clinical issues are particularly welcomed. Manuscripts dealing with the following areas are encouraged: -Clinical practice and management of hematological neoplasia, including: acute and chronic leukemias, malignant lymphomas, myeloproliferative disorders -Diagnostic investigations, including imaging and laboratory assays -Epidemiology, pathology and pathobiology of hematological neoplasia of hematological diseases -Therapeutic issues including Phase 1, 2 or 3 trials as well as allogeneic and autologous stem cell transplantation studies -Aspects of the cell biology, molecular biology, molecular genetics and cytogenetics of normal or diseased hematopoeisis and lymphopoiesis, including stem cells and cytokines and other regulatory systems. Concise, topical review material is welcomed, especially if it makes new concepts and ideas accessible to a wider community. Proposals for review material may be discussed with the Editor-in-Chief. Collections of case material and case reports will be considered only if they have broader scientific or clinical relevance.
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