弥漫性大b细胞淋巴瘤患者循环粘膜相关的不变T细胞减少，功能受损

IF 5 2区医学 Q2 Medicine

Translational Oncology Pub Date : 2025-06-27 DOI:10.1016/j.tranon.2025.102461

Jingru Liu , Jiadi Chen , Shucheng Chen , Yanrong Huang , Kaiming Xu , Danni Cai , Xinai Liao , Ruolan You , Xiaolin Xu , Xiaoting Wang , Diyu Hou , Shuxia Zhang , Fuwen Yang , Huifang Huang

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引用次数: 0

摘要

粘膜相关的不变性T （MAIT）细胞与肿瘤免疫有关。然而，它们在弥漫性大b细胞淋巴瘤（DLBCL）中的作用尚不清楚。因此，本研究旨在阐明DLBCL患者循环MAIT细胞的频率和功能特征。研究结果显示，与年龄匹配的健康对照相比，DLBCL患者循环MAIT细胞的频率显著降低。此外，来自DLBCL患者的循环MAIT细胞表现出促凋亡和衰老表型，并表现出功能障碍，激活和衰竭标志物（包括CD69、CD25、HLA-DR、PD-1和Tim-3）的表达升高证明了这一点。来源于DLBCL的MAIT细胞产生较低水平的关键抗肿瘤细胞因子，如干扰素- γ、白细胞介素-17、肿瘤坏死因子-α和颗粒酶B，表明抗肿瘤免疫功能受损。此外，与健康供者相比，来自DLBCL患者的MAIT细胞对DLBCL细胞的细胞毒性减弱。值得注意的是，DLBCL患者循环MAIT细胞的频率较低与预后不良有关。总之，本研究揭示了DLBCL患者循环MAIT细胞减少和受损，提示它们在抗淋巴瘤免疫中的重要性。

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Circulating mucosa-associated invariant T cells are decreased and have impaired function in patients with diffuse large B-cell lymphoma

Mucosa-associated invariant T (MAIT) cells are associated with tumor immunity. However, their role in diffuse large B-cell lymphoma (DLBCL) remains unclear. Therefore, this study aimed to elucidate frequency and functional characteristics of circulating MAIT cells in DLBCL patients. The findings revealed a significant reduction in the frequency of circulating MAIT cells in DLBCL patients compared to age-matched healthy controls. Moreover, circulating MAIT cells from DLBCL patients exhibited proapoptotic and senescent phenotypes and demonstrated dysfunction, as evidenced by elevated expression of activation and exhaustion markers, including CD69, CD25, HLA-DR, PD-1, and Tim-3. MAIT cells derived from DLBCL produced lower levels of crucial anti-tumor cytokines, such as interferon-gamma, interleukin-17, tumor necrosis factor-α and granzyme B, suggesting impaired anti-tumor immunity. Additionally, MAIT cells from DLBCL patients showed diminished cytotoxicity against DLBCL cells compared to those from healthy donors. Notably, a lower frequency of circulating MAIT cells in patients with DLBCL was associated with poor prognosis. In summary, this study reveals reduced and impaired circulating MAIT cells in DLBCL patients, suggesting their importance in anti-lymphoma immunity.

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来源期刊

Translational Oncology ONCOLOGY-

CiteScore

8.40

自引率

2.00%

发文量

314

审稿时长

54 days

期刊介绍： Translational Oncology publishes the results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of oncology patients. Translational Oncology will publish laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer. Peer reviewed manuscript types include Original Reports, Reviews and Editorials.