[人体小梁网流出通道的建模与有限元分析]。

Q4 Medicine
Shiya Bao, Qing Sun, Si Chen, Xinyu Chen, Xiang Peng, Jing Zhang
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引用次数: 0

摘要

青光眼是世界范围内不可逆失明的主要原因,其主要危险因素是由于房水产生和流出之间的不平衡导致眼压升高。本研究旨在通过三维建模和有限元分析,建立眼内压、虹膜力学特性、通道微观结构和房水动力学之间的定量相关性,克服传统实验技术在研究小梁网(TM)流出通道内水流动方面的局限性。基于人眼解剖,建立了包含层状TM结构、Schlemm管(SC)、虹膜和其他前段组织的三维流固相互作用(FSI)模型。FSI模拟量化IOP变化和虹膜杨氏模量对组织形态和房水动力学参数的影响。计算结果表明,虹膜轴向变形与眼压和虹膜杨氏模量有显著的相关性。虽然IOP升高对前后房水动力参数的影响很小,但它明显抑制了TM区域的水流速。此外,SC和收集器通道的壁面剪切应力对IOP变化非常敏感。这些发现揭示了组织力学- fsi机制通过调节房水动力学调节流出阻力,为开发青光眼治疗中降低IOP的临床治疗方法提供了有价值的参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Modeling and finite element analysis of human trabecular meshwork outflow pathways].

Glaucoma is the leading cause of irreversible blindness worldwide, with its primary risk factor arising from elevated intraocular pressure (IOP) due to an imbalance between aqueous humor production and outflow. This study aims to establish quantitative correlations among IOP, iris mechanical properties, channel microstructures, and aqueous humor dynamics through three-dimensional modeling and finite element analysis, overcoming the limitations of conventional experimental techniques in studying aqueous flow within the trabecular meshwork (TM) outflow pathway. A three-dimensional fluid-structure interaction (FSI) model incorporating the layered TM structure, Schlemm's canal (SC), iris, and other anterior segment tissues was developed based on human ocular anatomy. FSI simulations were performed to quantify the effects of IOP variations and iris Young's modulus on tissue morphology and aqueous humor dynamics parameters. The computational results demonstrated that axial iris deformation showed significant correlations with IOP and iris Young's modulus. Although elevated IOP exhibited minimal effects on hydrodynamic parameters in the anterior and posterior chambers, it markedly suppressed aqueous flow velocity in the TM region. Additionally, wall shear stress in SC and collector channels displayed high sensitivity to IOP variations. These findings reveal that the tissue mechanics-FSI mechanism modulates outflow resistance by regulating aqueous humor dynamics, offering valuable references for developing clinical therapies targeting IOP reduction in glaucoma management.

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来源期刊
生物医学工程学杂志
生物医学工程学杂志 Medicine-Medicine (all)
CiteScore
0.80
自引率
0.00%
发文量
4868
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