{"title":"空气污染与过敏性上呼吸道疾病的关系：一项荟萃分析","authors":"Zhi-Qiang Zhang, Jing-Yang Li, Qian Guo, Ya-Lun Li, You-Wei Bao, Yu-Qi Song, Dong-Xu Li, Jun Wu, Xin-Hua Zhu","doi":"10.1183/16000617.0266-2024","DOIUrl":null,"url":null,"abstract":"<p><p>The prevalence of allergic upper respiratory diseases is rising, and while air pollution may worsen them, study results vary, and comprehensive analyses are lacking. This study aimed to systematically evaluate the link between air pollution and these diseases (allergic rhinitis, asthma and chronic sinusitis (with/without nasal polyps)) to provide evidence for reducing their prevalence. A systematic search of PubMed, Embase, Web of Science and Scopus was conducted to find studies published up to 1 September 2024, regarding association between air pollution and allergic upper respiratory diseases. Meta-analyses calculated odds ratios and 95% confidence intervals for the outcomes. Sensitivity and subgroup analyses were performed to explore heterogeneity, and publication bias was assessed using Egger and Begg tests with funnel plots. We included 64 studies with 12 440 647 participants. The prevalence of allergic rhinitis, asthma and chronic sinusitis due to air pollution was 16%, 11% and 12%, respectively. Allergic rhinitis was linked to nitrogen dioxide (NO<sub>2</sub>) (OR 1.083), particulate matter with aerodynamic diameter <10 µm (PM<sub>10</sub>) (OR 1.026) and <2.5 µm (PM<sub>2.5</sub>) (OR 1.104), sulfur dioxide (SO<sub>2</sub>) (OR 1.116), ozone (OR 1.058) and carbon monoxide (CO) (OR 1.070). Asthma was associated with NO<sub>2</sub> (OR 1.146), PM<sub>2.5</sub> (OR 1.087), PM<sub>10</sub> (OR 1.037), polluted air (OR 1.038), ozone (OR 1.032), SO<sub>2</sub> (OR 1.090) and CO (OR 1.184). Chronic sinusitis was linked to PM<sub>2.5</sub> (OR 1.135), polluted air (OR 1.767), NO<sub>2</sub> (OR 1.091), SO<sub>2</sub> (OR 1.08), CO (OR 1.13), PM<sub>10</sub> (OR 1.22) and oxides of nitrogen (OR 1.18). Subgroup analyses showed that age (especially the young), region (especially in Europe), gender (especially men) and pollutant concentration (particularly high levels of pollution) affected these associations. Air pollution is positively correlated with prevalence of allergic rhinitis and asthma, increasing risk of allergic upper respiratory tract diseases.</p>","PeriodicalId":12166,"journal":{"name":"European Respiratory Review","volume":"34 176","pages":""},"PeriodicalIF":9.0000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220745/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between air pollution and allergic upper respiratory diseases: a meta-analysis.\",\"authors\":\"Zhi-Qiang Zhang, Jing-Yang Li, Qian Guo, Ya-Lun Li, You-Wei Bao, Yu-Qi Song, Dong-Xu Li, Jun Wu, Xin-Hua Zhu\",\"doi\":\"10.1183/16000617.0266-2024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The prevalence of allergic upper respiratory diseases is rising, and while air pollution may worsen them, study results vary, and comprehensive analyses are lacking. This study aimed to systematically evaluate the link between air pollution and these diseases (allergic rhinitis, asthma and chronic sinusitis (with/without nasal polyps)) to provide evidence for reducing their prevalence. A systematic search of PubMed, Embase, Web of Science and Scopus was conducted to find studies published up to 1 September 2024, regarding association between air pollution and allergic upper respiratory diseases. Meta-analyses calculated odds ratios and 95% confidence intervals for the outcomes. Sensitivity and subgroup analyses were performed to explore heterogeneity, and publication bias was assessed using Egger and Begg tests with funnel plots. We included 64 studies with 12 440 647 participants. The prevalence of allergic rhinitis, asthma and chronic sinusitis due to air pollution was 16%, 11% and 12%, respectively. Allergic rhinitis was linked to nitrogen dioxide (NO<sub>2</sub>) (OR 1.083), particulate matter with aerodynamic diameter <10 µm (PM<sub>10</sub>) (OR 1.026) and <2.5 µm (PM<sub>2.5</sub>) (OR 1.104), sulfur dioxide (SO<sub>2</sub>) (OR 1.116), ozone (OR 1.058) and carbon monoxide (CO) (OR 1.070). Asthma was associated with NO<sub>2</sub> (OR 1.146), PM<sub>2.5</sub> (OR 1.087), PM<sub>10</sub> (OR 1.037), polluted air (OR 1.038), ozone (OR 1.032), SO<sub>2</sub> (OR 1.090) and CO (OR 1.184). Chronic sinusitis was linked to PM<sub>2.5</sub> (OR 1.135), polluted air (OR 1.767), NO<sub>2</sub> (OR 1.091), SO<sub>2</sub> (OR 1.08), CO (OR 1.13), PM<sub>10</sub> (OR 1.22) and oxides of nitrogen (OR 1.18). Subgroup analyses showed that age (especially the young), region (especially in Europe), gender (especially men) and pollutant concentration (particularly high levels of pollution) affected these associations. Air pollution is positively correlated with prevalence of allergic rhinitis and asthma, increasing risk of allergic upper respiratory tract diseases.</p>\",\"PeriodicalId\":12166,\"journal\":{\"name\":\"European Respiratory Review\",\"volume\":\"34 176\",\"pages\":\"\"},\"PeriodicalIF\":9.0000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220745/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Respiratory Review\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1183/16000617.0266-2024\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/1 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Respiratory Review","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1183/16000617.0266-2024","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/1 0:00:00","PubModel":"Print","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Association between air pollution and allergic upper respiratory diseases: a meta-analysis.
The prevalence of allergic upper respiratory diseases is rising, and while air pollution may worsen them, study results vary, and comprehensive analyses are lacking. This study aimed to systematically evaluate the link between air pollution and these diseases (allergic rhinitis, asthma and chronic sinusitis (with/without nasal polyps)) to provide evidence for reducing their prevalence. A systematic search of PubMed, Embase, Web of Science and Scopus was conducted to find studies published up to 1 September 2024, regarding association between air pollution and allergic upper respiratory diseases. Meta-analyses calculated odds ratios and 95% confidence intervals for the outcomes. Sensitivity and subgroup analyses were performed to explore heterogeneity, and publication bias was assessed using Egger and Begg tests with funnel plots. We included 64 studies with 12 440 647 participants. The prevalence of allergic rhinitis, asthma and chronic sinusitis due to air pollution was 16%, 11% and 12%, respectively. Allergic rhinitis was linked to nitrogen dioxide (NO2) (OR 1.083), particulate matter with aerodynamic diameter <10 µm (PM10) (OR 1.026) and <2.5 µm (PM2.5) (OR 1.104), sulfur dioxide (SO2) (OR 1.116), ozone (OR 1.058) and carbon monoxide (CO) (OR 1.070). Asthma was associated with NO2 (OR 1.146), PM2.5 (OR 1.087), PM10 (OR 1.037), polluted air (OR 1.038), ozone (OR 1.032), SO2 (OR 1.090) and CO (OR 1.184). Chronic sinusitis was linked to PM2.5 (OR 1.135), polluted air (OR 1.767), NO2 (OR 1.091), SO2 (OR 1.08), CO (OR 1.13), PM10 (OR 1.22) and oxides of nitrogen (OR 1.18). Subgroup analyses showed that age (especially the young), region (especially in Europe), gender (especially men) and pollutant concentration (particularly high levels of pollution) affected these associations. Air pollution is positively correlated with prevalence of allergic rhinitis and asthma, increasing risk of allergic upper respiratory tract diseases.
期刊介绍：
The European Respiratory Review (ERR) is an open-access journal published by the European Respiratory Society (ERS), serving as a vital resource for respiratory professionals by delivering updates on medicine, science, and surgery in the field. ERR features state-of-the-art review articles, editorials, correspondence, and summaries of recent research findings and studies covering a wide range of topics including COPD, asthma, pulmonary hypertension, interstitial lung disease, lung cancer, tuberculosis, and pulmonary infections. Articles are published continuously and compiled into quarterly issues within a single annual volume.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
