白三烯:弥合哮喘和炎症性肠病(IBD)的炎症间隙。

IF 4.2 2区 医学 Q1 PHYSIOLOGY
Emma Elizabeth Sabu Kattuman, Lakshminarayan Reddy Teegala, Somayeh Darzi, Charles K Thodeti, Sailaja Paruchuri
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引用次数: 0

摘要

白三烯是主要由免疫细胞产生的强效炎性脂质介质。炎症是哮喘和炎症性肠病(IBD)这两种主要疾病的核心,因此研究人员广泛研究白三烯(LTs)在这两种疾病中的作用。几项研究表明,LTs在IBD的发生和进展中起着至关重要的作用,而LTs,特别是半胱氨酸白三烯(cys-LTs),在过去30多年中被确定为哮喘发生和进展的主要因素。此外,肺和肠道有几个共同的特征,包括它们暴露于外部环境,相似的微生物组组成和炎症反应。这些相似之处表明了一种双向关系,哮喘患者患IBD的风险增加,反之亦然。然而,LTs在这种肺-肠连接中的具体作用尚不清楚。这篇综述将探讨几个常见的因素,如生理、微生物组、环境和炎症介质,特别是lt,如何调节这种串扰。该综述还详细强调了白三烯生物合成和信号传导的改变如何促进哮喘和IBD的发病机制。此外,我们将考虑靶向白三烯途径对并发哮喘和IBD患者的治疗意义,以期为这些相互关联的疾病开发更有效的治疗结果。最后,本文将简要探讨神经元连接在介导肺肠串扰中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Leukotrienes: Bridging the Inflammatory Gap in Asthma and Inflammatory Bowel Diseases (IBD).

Leukotrienes are potent inflammatory lipid mediators produced primarily by immune cells. Inflammation, being the center stone of two major disease conditions, namely, asthma and inflammatory bowel disease (IBD), has led researchers to study the role of leukotrienes (LTs) in both these disease settings extensively. Several studies indicate a crucial role for LTs in the development and progression of IBD, whereas LTs, especially cysteinyl leukotrienes (cys-LTs), have been identified as the major contributors to asthma initiation and progression for over three decades. Additionally, the lungs and the gut share several common characteristics, including their exposure to the external environment, similar microbiome composition, and inflammatory responses. These similarities suggest a bidirectional relationship, supported by the increased risk of IBD in asthma patients and vice versa. However, the specific role of LTs in this lung-gut connection remains unclear. This review will examine how several common factors, such as physiology, microbiome, environment, and inflammatory mediators, especially LTs, modulate this crosstalk. The review also highlights in detail how altered leukotriene biosynthesis and signaling contribute to the pathogenesis of both asthma and IBD. Furthermore, we will consider the therapeutic implications of targeting leukotriene pathways for patients with concurrent asthma and IBD in the hope of developing more efficient treatment outcomes for these interconnected conditions. Finally, this review will very briefly explore the involvement of neuronal connections in mediating the lung-gut crosstalk.

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来源期刊
CiteScore
10.50
自引率
0.00%
发文量
38
审稿时长
6-12 weeks
期刊介绍: Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.
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