表没食子儿茶素没食子酸酯治疗和预防皮炎的有效性和安全性:系统综述。

IF 3.9 3区 工程技术 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Katarzyna Śladowska, Paweł Moćko, Tomasz Brzostek, Iwona Malinowska-Lipień, Michał Owca, Paweł Kawalec
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引用次数: 0

摘要

背景/目的:表没食子儿茶素没食子酸酯(EGCG)是绿茶中含量最多的儿茶素。根据体外研究的结果,egcg具有广泛的有益特性,被认为是治疗各种皮肤疾病的有希望的选择。方法:本系统综述的目的是评估EGCG治疗和预防各种类型皮炎的有效性和安全性,根据系统综述和荟萃分析的首选报告项目(PRISMA)指南进行。结果:PubMed、Embase、CENTRAL和ClinicalTrials.gov数据库的检索确定了8项试验(包括4项随机试验),这些试验调查了EGCG单独(作为生理盐水溶液)用于治疗和预防辐射引起的皮炎,或作为特应性和脂流性头皮皮炎的洗发水或面膏的成分。已确定的单臂和随机对照试验的特点是方法学质量较低,处于早期发展阶段,和/或参与者人数较少。EGCG对皮炎严重程度的局部作用取决于皮炎的类型、浓度和使用的药物形式。与安慰剂和基线相比,EGCG的使用导致辐射性皮炎患者的皮肤症状显著减轻,而在头皮脂溢性皮炎中,含有EGCG成分的洗发水的结果与积极的常规治疗相似。EGCG治疗总体耐受良好,无严重的治疗相关不良事件。结论:本研究表明,EGCG可作为治疗和预防各种类型皮炎的有希望的选择。然而,由于样本量小,需要大规模、精心设计的随机III期试验来证实其安全性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and Safety of Epigallocatechin Gallate in the Treatment and Prevention of Dermatitis: A Systematic Review.

Background/Objectives: Epigallocatechin gallate (EGCG) is the most abundant catechin in green tea. Based on results from in vitro studies, EGCG-with its wide range of beneficial properties-has been considered a promising option for the treatment of patients with various skin conditions. Methods: The aim of this systematic review, conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, was to evaluate the efficacy and safety of EGCG in the treatment and prevention of various types of dermatitis. Results: A search of PubMed, Embase, CENTRAL, and ClinicalTrials.gov databases identified eight trials (including four randomized trials) that investigated the use of EGCG alone (as a saline solution) for the treatment and prevention of radiation-induced dermatitis or as a component of a shampoo or cream for atopic and seborrheic scalp dermatitis. The identified single-arm and randomized controlled trials were characterized by low methodological quality, were in early phases of development, and/or included a small number of participants. The topical effect of EGCG on the severity of dermatitis was shown to depend on the type of dermatitis, concentration, and pharmaceutical form used. The administration of EGCG resulted in a significant reduction in skin symptoms in patients with radiation-induced dermatitis compared with placebo and with baseline, while in seborrheic dermatitis of the scalp, the results of shampoo with EGCG component were similar to those of active conventional treatment. The EGCG treatment was generally well tolerated, with no serious treatment-related adverse events. Conclusions: This study showed that EGCG can be a promising option for the treatment and prevention of various types of dermatitis. However, due to the small sample size, large, well-designed, randomized phase III trials are needed to confirm its safety and efficacy.

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来源期刊
Biomedicines
Biomedicines Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.20
自引率
8.50%
发文量
2823
审稿时长
8 weeks
期刊介绍: Biomedicines (ISSN 2227-9059; CODEN: BIOMID) is an international, scientific, open access journal on biomedicines published quarterly online by MDPI.
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