星形胶质细胞微域钙活性的研究进展

Q3 Medicine
Fu-Sheng Ding, Si-Si Yang, Liang Zheng, Dan Mu, Zhu Huang, Jian-Xiong Zhang
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引用次数: 0

摘要

星形胶质细胞是中枢神经系统中重要的一类胶质细胞,不仅维持脑内稳态,还积极参与脑内信息的传递。星形胶质细胞具有复杂的结构,包括胞体、不同层次的突起和端足。随着基因编码钙指标和成像技术的进步,研究人员在精细突起和端足中发现了许多局部和小的钙活性。这些钙活性被称为微域钙活性,它与体细胞内的钙活性有很大不同,可以影响局部神经元、突触和血管的活性。本文阐述了微结构域钙活性的检测与分析、特征、来源和功能,并讨论了衰老和神经退行性疾病对这些活性的影响,旨在加深对星形胶质细胞在大脑中的作用的认识,为脑部疾病的治疗提供新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Research progress on calcium activities in astrocyte microdomains].

Astrocytes are a crucial type of glial cells in the central nervous system, not only maintaining brain homeostasis, but also actively participating in the transmission of information within the brain. Astrocytes have a complex structure that includes the soma, various levels of processes, and end-feet. With the advancement of genetically encoded calcium indicators and imaging technologies, researchers have discovered numerous localized and small calcium activities in the fine processes and end-feet. These calcium activities were termed as microdomain calcium activities, which significantly differ from the calcium activities in the soma and can influence the activity of local neurons, synapses, and blood vessels. This article elaborates the detection and analysis, characteristics, sources, and functions of microdomain calcium activities, and discusses the impact of aging and neurodegenerative diseases on these activities, aiming to enhance the understanding of the role of astrocytes in the brain and to provide new insights for the treatment of brain disorders.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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