Psoriasis

Psoriasis is a chronic, immune-mediated skin condition affecting millions of individuals globally, including around 1.3–2.8% people in the UK. It is characterized by rapid turnover of skin cell leading to the build-up of thick scaly plaques. The disease has a complex pathophysiology involving genetics, immune dysregulation and environmental factors. There are multiple subtypes, chronic plaque psoriasis being the most prevalent. It commonly affects areas such as the extensor surfaces of the limbs, scalp, trunk and nails. Early diagnosis and treatment are helpful as the condition can severely impact quality of life. Psoriasis is also associated with several co-morbidities, including psoriatic arthritis, metabolic syndrome, cardiovascular disease and psychological issues. Treatment options include topical therapies, phototherapy, systemic medications, immunosuppression and injectable biologic agents, with continuing research driving further advancements.