开发一种多功能深度热疗治疗计划工具

IF 2.7 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Physica Medica-European Journal of Medical Physics Pub Date : 2025-06-27 DOI:10.1016/j.ejmp.2025.105035

Tomas Drizdal , Margarethus M. Paulides , Daniel de Jong , Marek Novak , Tomas Pokorny , Zdenek Linha , Jakub Kollar , Martine Franckena , Ondrej Fiser , Sergio Curto , Gerard C. van Rhoon

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引用次数: 0

摘要

目的开发和测试一种多功能深度热疗治疗计划（HTP）工具。方法采用一种新开发的多功能HTP工具，对临床手动操作的病人自动定位程序进行实施。对于70例使用Sigma 60涂抹器治疗的患者和48例使用Sigma Eye涂抹器治疗的患者，我们比较了人工和自动定位程序获得的预测特定吸收率（SAR）指标。我们使用目标与热点系数（THQ）表示目标与热点的平均SAR之比，TC25和TC50定义为25%和50% SAR等等值线包围的目标体积。此外，我们创建了Sigma Ellipse， Alba4D和AMC8应用程序的示例http设置，展示了该工具的多功能性。结果对于Sigma 60和Sigma Eye，我们发现在比较手动和自动创建的HTP设置时，所有研究的SAR指标的最高平均相对差异为2%。总的来说，自动定位过程是非常高效的，操作员建立单个患者特定HTP设置的时间要快10-20分钟。结论平均而言，与经验丰富的人工定位相比，自动定位程序更具时间效率，并提供相似的SAR目标覆盖率。减少的时间要求支持HTP在临床常规中得到更广泛的接受。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Development of a versatile deep hyperthermia treatment planning tool

Purpose

To develop and test a versatile deep hyperthermia treatment planning (HTP) tool.

Methods

A patient automatic positioning routine following manual clinical procedure was implemented into a newly developed versatile HTP tool. For 70 patients treated using Sigma 60 applicator, 48 patients with the Sigma Eye applicator, we compared predicted specific absorption rate (SAR) indicators obtained by manual and automatic positioning routines. We used the target to hotspot coefficient (THQ) representing the ratio between average SAR in target and hotspot, TC25 and TC50 defined as target volume enclosed with 25% and 50% SAR iso-contour. Further, we created example HTP setups for Sigma Ellipse, Alba4D and AMC8 applicators demonstrating the versatility of the tool.

Results

For the Sigma 60 and the Sigma Eye, we found a highest average relative difference of 2% for all studied SAR indicators when comparing manual and automatically created HTP setups. Overall, the automatic positioning procedure is highly efficient and operator time for building a single patient specific HTP setup is 10–20 min faster.

Conclusion

On average, the automatic positioning routine is more time efficient and provides similar SAR target coverage compared to manual positioning by experienced staff. The reduced time requirement supports wider HTP acceptance in the clinical routine.

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来源期刊

Physica Medica-European Journal of Medical Physics 生物-生物物理

CiteScore

6.80

自引率

14.70%

发文量

493

审稿时长

78 days

期刊介绍： Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics: Medical Imaging Radiation Therapy Radiation Protection Measuring Systems and Signal Processing Education and training in Medical Physics Professional issues in Medical Physics.