CRISPR-Cas9系统在骨关节炎研究和治疗中的潜在应用

Long Liang, YaXuan Yang, Fiore Jacqueline Elise, Jie Yu, Xunlu Yin, Guangqi Lu, Bin Chen, Jianhua Xing
{"title":"CRISPR-Cas9系统在骨关节炎研究和治疗中的潜在应用","authors":"Long Liang, YaXuan Yang, Fiore Jacqueline Elise, Jie Yu, Xunlu Yin, Guangqi Lu, Bin Chen, Jianhua Xing","doi":"10.1055/a-2616-0819","DOIUrl":null,"url":null,"abstract":"<p><p>Osteoarthritis is a common degenerative disease of joint cartilage that affects millions of people in the world, especially the elderly. Progression of osteoarthritis is associated with a plethora of genetic and non-genetic factors. The CRISPR/Cas9 system is emerging as a powerful tool for genome engineering and has remarkable potential for guiding further research into osteoarthritis and may be a viable means for treating the disease. This review discusses existing and potential applications of the CRISPR/Cas9 system in osteoarthritis studies and treatments. Firstly, we briefly summarize the current status and mechanism of this technology. Next, we focus on the latest advances in the application of CRISPR/Cas9 system in elucidating the contributions of various factors to the pathogenesis of osteoarthritis as demonstrated through in vitro studies and animal models. Finally, we provide our perspective on the direction and challenges of studying and treating osteoarthritis with CRISPR/Cas9.</p>","PeriodicalId":94274,"journal":{"name":"Zeitschrift fur Orthopadie und Unfallchirurgie","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Potential Applications of the CRISPR-Cas9 System for Research and Treatment of Osteoarthritis.\",\"authors\":\"Long Liang, YaXuan Yang, Fiore Jacqueline Elise, Jie Yu, Xunlu Yin, Guangqi Lu, Bin Chen, Jianhua Xing\",\"doi\":\"10.1055/a-2616-0819\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Osteoarthritis is a common degenerative disease of joint cartilage that affects millions of people in the world, especially the elderly. Progression of osteoarthritis is associated with a plethora of genetic and non-genetic factors. The CRISPR/Cas9 system is emerging as a powerful tool for genome engineering and has remarkable potential for guiding further research into osteoarthritis and may be a viable means for treating the disease. This review discusses existing and potential applications of the CRISPR/Cas9 system in osteoarthritis studies and treatments. Firstly, we briefly summarize the current status and mechanism of this technology. Next, we focus on the latest advances in the application of CRISPR/Cas9 system in elucidating the contributions of various factors to the pathogenesis of osteoarthritis as demonstrated through in vitro studies and animal models. Finally, we provide our perspective on the direction and challenges of studying and treating osteoarthritis with CRISPR/Cas9.</p>\",\"PeriodicalId\":94274,\"journal\":{\"name\":\"Zeitschrift fur Orthopadie und Unfallchirurgie\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift fur Orthopadie und Unfallchirurgie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/a-2616-0819\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Orthopadie und Unfallchirurgie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/a-2616-0819","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

骨关节炎是一种常见的关节软骨退行性疾病,影响着世界上数百万人,尤其是老年人。骨关节炎的进展与过多的遗传和非遗传因素有关。CRISPR/Cas9系统正在成为基因组工程的强大工具,在指导骨关节炎的进一步研究方面具有显著的潜力,并且可能是治疗这种疾病的可行方法。本文综述了CRISPR/Cas9系统在骨关节炎研究和治疗中的现有和潜在应用。首先,我们对该技术的现状和机理进行了简要的总结。接下来,我们将重点介绍CRISPR/Cas9系统在体外研究和动物模型中阐明各种因素对骨关节炎发病机制的贡献方面的最新进展。最后,我们对CRISPR/Cas9研究和治疗骨关节炎的方向和挑战提出了自己的看法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential Applications of the CRISPR-Cas9 System for Research and Treatment of Osteoarthritis.

Osteoarthritis is a common degenerative disease of joint cartilage that affects millions of people in the world, especially the elderly. Progression of osteoarthritis is associated with a plethora of genetic and non-genetic factors. The CRISPR/Cas9 system is emerging as a powerful tool for genome engineering and has remarkable potential for guiding further research into osteoarthritis and may be a viable means for treating the disease. This review discusses existing and potential applications of the CRISPR/Cas9 system in osteoarthritis studies and treatments. Firstly, we briefly summarize the current status and mechanism of this technology. Next, we focus on the latest advances in the application of CRISPR/Cas9 system in elucidating the contributions of various factors to the pathogenesis of osteoarthritis as demonstrated through in vitro studies and animal models. Finally, we provide our perspective on the direction and challenges of studying and treating osteoarthritis with CRISPR/Cas9.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信