m6A修饰和r -环的动态相互作用:对基因组稳定性的影响。

IF 2.5 Q3 GENETICS & HEREDITY
Nicholas Kim, Hong Sun
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引用次数: 0

摘要

r环是一种三链RNA-DNA杂交核酸结构,在生理和病理过程中都发挥着重要作用。r环的调控对基因组稳定至关重要,因为r环稳态的破坏可能导致基因表达异常、复制应激和DNA损伤。最近的研究表明,RNA修饰n6 -甲基腺苷(m6A)可以修饰r -环,m6A的写子、擦子和读子参与r -环的动态调控。在这里,我们讨论了与r环相关的各种m6A调节蛋白的功能,强调了它们在识别和调节这些结构的形成、稳定性和分辨率方面的独特作用。我们进一步研究了m6A和R-loop相互作用在人类疾病中的功能意义,特别强调了它们在癌症中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Dynamic Interactions of m6A Modification and R-Loops: Implications for Genome Stability.

R-loops, three-stranded RNA-DNA hybrid nucleic acid structures, are recognized for their roles in both physiological and pathological processes. Regulation of R-loops is critical for genome stability as disruption of R-loop homeostasis can lead to aberrant gene expression, replication stress, and DNA damage. Recent studies suggest that the RNA modification, N6-methyladenosine (m6A), can modify R-loops and the writers, erasers, and readers of m6A are involved in the dynamic regulation of R-loops. Here, we discuss the reported functions of various m6A regulatory proteins in relation to R-loops, highlighting their distinct roles in recognizing and modulating the formation, stability, and resolution of these structures. We further examine the functional implications of m6A and R-loop interaction in human diseases, with a particular emphasis on their roles in cancer.

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来源期刊
Epigenomes
Epigenomes GENETICS & HEREDITY-
CiteScore
3.80
自引率
0.00%
发文量
38
审稿时长
11 weeks
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