帕金森病α -突触核蛋白种子扩增试验:系统综述和网络荟萃分析。

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
Jamir Pitton Rissardo, Ana Leticia Fornari Caprara
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引用次数: 0

摘要

前言和目的:评价α-突触核蛋白(αSyn)种子扩增试验(αSyn- saa)在脑脊液(CSF)、血液、皮肤、细胞外囊泡(ECV)、唾液、嗅觉粘膜(OM)、胃肠道(GIT)和颌下腺(SMG)鉴别帕金森病(PD)和对照组中的准确性。方法:检索PubMed从2010年到2025年1月的文章。质量评价采用robvis。获得了具有95%置信区间(CI)的诊断值。进行z检验、Wald CI和方差分析。采用诊断优势比(DOR)。结果:αSyn-SAAs在区分PD与不同组织和液体类型的对照中表现出较强的诊断性能。总体而言,αSyn-SAAs具有较高的灵敏度(86%)和特异性(92%)。在所有生物基质中,CSF、皮肤、血液和ECV的诊断准确性最高,敏感性和特异性接近或超过90%。相比之下,唾液、口腔黏膜和胃肠道样本的敏感性较低,但特异性仍然相对较高。ECV、CSF、皮肤和血液基质也显示出最高的DOR,支持其潜在的临床应用。结论:ECV和血液在αSyn-SAA中具有较高的准确性和最小的侵入性,而GIT、OM和口腔样本的实用性有限;唾液和SMG需要改进。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alpha-Synuclein Seed Amplification Assays in Parkinson's Disease: A Systematic Review and Network Meta-Analysis.

Introduction and objective: Assessment of α-synuclein (αSyn) seed amplification assays (αSyn-SAA) accuracy in distinguishing Parkinson's disease (PD) from controls using cerebrospinal fluid (CSF), blood, skin, extracellular vesicles (ECV), saliva, olfactory mucosa (OM), gastrointestinal tract (GIT), and submandibular gland (SMG).

Methodology: PubMed was searched for articles from 2010 to January 2025. The quality assessment used robvis. Diagnostic values with a 95% confidence interval (CI) were obtained. Z-test, Wald CI, and ANOVA were performed. Diagnostic odds ratio (DOR) was used.

Results: αSyn-SAAs showed strong diagnostic performance in distinguishing PD from controls across various tissue and fluid types. Overall, αSyn-SAAs demonstrated high sensitivity (86%) and specificity (92%). Among all biomatrices, CSF, skin, blood, and ECV yielded the highest diagnostic accuracy, with sensitivity and specificity approaching or exceeding 90%. In contrast, saliva, oral mucosa, and gastrointestinal tract samples showed more modest sensitivity, though specificity remained relatively high. ECV, CSF, skin, and blood matrices also demonstrated the highest DOR, supporting their potential clinical utility.

Conclusions: ECV and blood warrant priority in αSyn-SAA for high accuracy and minimal invasiveness, while GIT, OM, and oral samples show limited utility; saliva and SMG need refinement.

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来源期刊
Clinics and Practice
Clinics and Practice MEDICINE, GENERAL & INTERNAL-
CiteScore
2.60
自引率
4.30%
发文量
91
审稿时长
10 weeks
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