利用流行的机器学习方法进行植物性状的基因组预测。

IF 1 Q3 AGRICULTURE, MULTIDISCIPLINARY
K N Kozlov, M P Bankin, E A Semenova, M G Samsonova
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引用次数: 0

摘要

基因组数据的快速增长使得在基因组预测和鉴定snp与表型性状的关联方面获得广泛的结果成为可能。在许多情况下,为了确定表型和基因型之间的新关系,最好使用机器学习、深度学习和人工智能,特别是能够识别复杂模式的可解释人工智能。人工选择80个来源;虽然对发布日期没有限制,但主要关注的是用于基因组预测的拟议方法的独创性。本文考虑了基因组预测模型、卷积神经网络、可解释人工智能和大型语言模型。重点研究了数据增强、迁移学习、降维方法和混合方法。在模型解解释的特定模型和独立模型方法领域的研究主要分为三类:感知模型、摄动模型和替代模型。所考虑的例子反映了这一研究领域的主要现代趋势。报告指出,大型语言模型,包括那些基于转换器的模型,在遗传密码处理方面的作用越来越大,数据增强方法的发展也越来越大。在混合方法中,强调了将机器学习模型与基于生物物理和生化过程的植物发育模型相结合的前景。由于机器学习和人工智能的方法是各个应用领域的专家和基础科学家关注的焦点,也引起了公众的共鸣,因此致力于这些主题的作品的数量正在爆炸式增长。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genomic prediction of plant traits by popular machine learning methods.

A rapid growth of the available body of genomic data has made it possible to obtain extensive results in genomic prediction and identification of associations of SNPs with phenotypic traits. In many cases, to identify new relationships between phenotypes and genotypes, it is preferable to use machine learning, deep learning and artificial intelligence, especially explainable artificial intelligence, capable of recognizing complex patterns. 80 sources were manually selected; while there were no restrictions on the release date, the main attention was paid to the originality of the proposed approach for use in genomic prediction. The article considers models for genomic prediction, convolutional neural networks, explainable artificial intelligence and large language models. Attention is paid to Data Augmentation, Transfer Learning, Dimensionality Reduction methods and hybrid methods. Research in the field of model-specific and model-independent methods for interpretation of model solutions is represented by three main categories: sensing, perturbation, and surrogate model. The considered examples reflect the main modern trends in this area of research. The growing role of large language models, including those based on transformers, for genetic code processing, as well as the development of data augmentation methods, are noted. Among hybrid approaches, the prospect of combining machine learning models and models of plant development based on biophysical and biochemical processes is emphasized. Since the methods of machine learning and artificial intelligence are the focus of attention of both specialists in various applied fields and fundamental scientists, and also cause public resonance, the number of works devoted to these topics is growing explosively.

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来源期刊
Vavilovskii Zhurnal Genetiki i Selektsii
Vavilovskii Zhurnal Genetiki i Selektsii AGRICULTURE, MULTIDISCIPLINARY-
CiteScore
1.90
自引率
0.00%
发文量
119
审稿时长
8 weeks
期刊介绍: The "Vavilov Journal of genetics and breeding" publishes original research and review articles in all key areas of modern plant, animal and human genetics, genomics, bioinformatics and biotechnology. One of the main objectives of the journal is integration of theoretical and applied research in the field of genetics. Special attention is paid to the most topical areas in modern genetics dealing with global concerns such as food security and human health.
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