双功能荧光探针用于神经元反式分化：一种有前途的神经再生研究治疗策略。

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

ACS Chemical Neuroscience Pub Date : 2025-06-25 DOI:10.1021/acschemneuro.5c00367

Pratikshya Paudel, Prabir Kumar Gharai

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引用次数: 0

摘要

神经退行性疾病导致进行性神经元丧失，目前的治疗只能提供有限的症状缓解。为了克服这一点，正在探索各种策略。一种很有前景的方法是利用小分子将人间充质干细胞（hMSCs）转化为功能性神经元，同时使用荧光探针进行实时成像。因此，开发一种结合分化诱导和成像能力而不依赖生长因子的有前途的单一化合物可以显著推进神经科学研究中的神经再生治疗和诊断策略。

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Dual-Function Fluorescent Probes for Neuronal Trans-Differentiation: A Promising Therapeutic Strategy in Neuroregenerative Research.

Neurodegenerative diseases cause progressive neuronal loss, with current treatments offering only limited symptomatic relief. To overcome this, various strategies are being explored. One promising approach involves converting human mesenchymal stem cells (hMSCs) into functional neurons using a small molecule, alongside the use of fluorescent probes for real-time imaging. Therefore, developing a promising single compound that combines both differentiation-inducing and imaging capabilities without relying on growth factors could significantly advance neuroregenerative therapies and diagnostic strategies in neuroscience research.

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来源期刊

ACS Chemical Neuroscience BIOCHEMISTRY & MOLECULAR BIOLOGY-CHEMISTRY, MEDICINAL

CiteScore

9.20

自引率

4.00%

发文量

323

审稿时长

1 months

期刊介绍： ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical and bioengineering approaches to the understanding of the nervous system and to the development of new treatments for neurological disorders. Research in the journal focuses on aspects of chemical neurobiology and bio-neurochemistry such as the following: Neurotransmitters and receptors Neuropharmaceuticals and therapeutics Neural development—Plasticity, and degeneration Chemical, physical, and computational methods in neuroscience Neuronal diseases—basis, detection, and treatment Mechanism of aging, learning, memory and behavior Pain and sensory processing Neurotoxins Neuroscience-inspired bioengineering Development of methods in chemical neurobiology Neuroimaging agents and technologies Animal models for central nervous system diseases Behavioral research